Firm wins $65 million contract for botulism treatments

first_img The contract is the third one that the National Institute of Allergy and Infectious Diseases (NIAID) has awarded Xoma to develop botulism antitoxins, the company said in a Sep 9 statement. In 2005 Xoma was among the first companies to receive a contract through Project BioShield, according to a previous report. Xoma reported that  its NIAID contracts cover the development of human monoclonal antibody products targeting the three most toxic serotypes of botulinum toxin, types A, B,and E. The company also said these human antibody products are expected to be safer than existing animal-derived antibodies, which it said cause serious immune reactions in some patients and vary unpredictably in their efficacy. See also: Sep 11, 2008 (CIDRAP News) – Xoma Ltd., a Berkeley, Calif., pharmaceutical company, recently announced that it received a $65 million multiyear federal contract to fund work on botulinum antitoxins, one of which it hopes to put through safety and efficacy tests starting in 2009. Clostridium botulinum, which produces botulinum toxin, a nerve poison, is among the category A agents that experts say bioterrorists would most likely try to use. However, most botulism cases are caused by tainted food or contaminated wounds. Sep 9 Xoma press release Steven Engle, Xoma’s chairman and chief executive officer, said in the statement that the contract shows the US government’s support of novel therapies that address natural, accidental, or intentional infections from pathogens and their toxins. “Since initiating its biodefense program in 2005, Xoma has used its innovative antibody technology to develop better and safe solutions,” he said. “We plan to continue working with the government’s biodefense development efforts toward future stockpiling initiatives.” Xoma said if studies show that the company’s first botulism antitoxin candidate is safe and effective and government funding continues, it would file the paperwork needed to produce the treatment for the Strategic National Stockpile. The new NIAID contract will cover the next 6 years of botulism antitoxin development, the company said. May 10, 2005, CIDRAP News story “NIAID awards first Project BioShield grants”last_img read more

From now on, apartments on the island of Vir can be paid in cryptocurrencies

first_imgWith ninety-six apartments that have recently been offered the possibility of advance payment and reservation of accommodation via cryptocurrencies on the Slovak blog Vir Island, and given the size of the island, population and number of accommodation units, Vir has become one of the world’s leading providers of crypto services. Source / photo: Vir Tourism; Pexels Cryptocurrencies, known as virtual or digital currencies, exist only online; they have not been issued, nor are they supervised by any central bank. Bitcoin is the most famous cryptocurrency, also known as digital gold, and is globally accepted for online payments. Today, several bitcoin ATMs also exist in Croatia – in Zagreb, Split and Rijeka, and the popularity of using bitcoin is also contributed by entrepreneurs, such as Virco, who accept it in online payments for tourist accommodation or other services. Ms. Miriam is the most influential Slovak woman from Vir and the promoter of Vir in Slovakia and the Czech Republic, so through her work and bringing the Travel Channel television team to Vir, the island has a thriving Slovak tourist market. Vir influencer and blogger is also a Slovak and Czech association of apartment and apartment owners on the island of Vir, some of whom have already started receiving payments for payments in cryptocurrencies BTC, BCH, LTC, ETH and USDC. According to Arbolet, the service is connected to the Coinbase Commerce system, whose user interface is simple, intuitive to use and above all easy to understand. “I’ve been thinking for a long time about the possibility of paying with cryptocurrencies, but I didn’t know the area well enough. Mr. Václav helped me the most”, Says Ms. Miriam, thanks to which accommodation in Vir can now be paid for in cryptocurrency, ie by booking through her blog Island Vir. These 96 apartments paid in cryptocurrency represent 2,51 percent of the total Vir accommodation capacity of 3.819 accommodation units. In fact, the percentage in foreign exchange is higher because the number of apartments is an absolute number of one hundred percent occupancy with payment by card or cash, which means that the share of cryptocurrency in foreign exchange by the summer season will certainly be even higher. Apart from the fact that cryptocurrencies are used for online payments, they are traded like any other currency. Thus, the value of bitcoin nine years ago was $ 0,003, and last year it was more than $ 9.000. Today, there are hundreds of other cryptocurrencies and new ones appear almost every day. Some survive and grow, some die out, but the growth of the crypto market is steady. That is why more and more online stores are offering cryptocurrency payments, while digital wallet owners want offers in which they can exchange their cryptocurrency units for products or services. This story was recently published by the Czech portal Arbolet, whose online team provides consulting and work services in the crypto market. Their member Václav got in touch with Miriam Kelečić, who edits the blog and mediates in renting apartments in Vir to tourists from Slovakia and the Czech Republic, so the island’s crypto market is almost immediately open to members of this large community.last_img read more

Niche market

first_imgTo access this article REGISTER NOWWould you like print copies, app and digital replica access too? SUBSCRIBE for as little as £5 per week. Would you like to read more?Register for free to finish this article.Sign up now for the following benefits:Four FREE articles of your choice per monthBreaking news, comment and analysis from industry experts as it happensChoose from our portfolio of email newsletterslast_img

US narrowing support to seven COVID-19 vaccine candidates, expects them to be free for many

first_imgThe Trump administration aims to narrow its financial support to about seven experimental coronavirus vaccines from the 14 it has been working with so far, the US Department of Health and Human Services (HHS) said on Tuesday.US government officials also said that they expect many Americans to get an approved vaccine to prevent COVID-19 at no charge once it begins distribution, potentially in January.“For any American who is vulnerable, who cannot afford the vaccines, and desires the vaccine, we will provide it for free,” a US government official said during a call with reporters, requesting anonymity. Topics : The Trump Administration previously announced it has put more than $2 billion behind three vaccines in development, one being tested by AstraZeneca Plc along with the University of Oxford, a Moderna Inc candidate and one from Johnson & Johnson. It has also given more than $30 million each to Merck & Co and Sanofi SA for their separate vaccine efforts.A government official said it was still deliberating which companies would ultimately be among those it will support, based on the success of closely watched trials and manufacturing capability.The New York Times reported earlier this month that the White House had selected five companies: Moderna, AstraZeneca, Pfizer Inc, J&J and Merck. center_img The official also said that based on conversations with commercial health insurers, it expects a vaccine to be covered with no out-of-pocket costs, similar to coverage policies insurers have put in place for COVID-19 related medical services.”We will be working with insurers,” the official said.The Trump Administration last month launched “Operation Warp Speed” – a joint HHS and Department of Defense program – to accelerate development of coronavirus vaccines, treatments and diagnostics.The effort has “maximized the possibility” of having a vaccine before year end, the government official said.last_img read more

What’s the magic number to clinch a playoff berth in a 60-game MLB season?

first_imgMORE: Why the Padres, A’s and Mets could surprise in a 60-game season Vegas odds Odds Shark released its win totals for the 60-game season, and the Yankees and Dodgers have the highest number at 37.5 each. Those two — which will be heavy World Series favorites even in the new format — are the only teams picked to win more than 35 games.  Houston is next at 35, followed by Minnesota at 34.5. Atlanta, Tampa Bay and Washington are at 34. That list provides five of the six division winners from last season — with the Cardinals the other team. St. Louis is at 32.5.  By these numbers, any team that gets to 35-38 victories should be good for a playoff berth.  That might not be enough to win the division, however.  2019 division winners  We totaled the winning percentage for the six division winners from 2019, and that number is .622. If you are targeting that winning percentage over a 60-game season, then the closest record would be 37-23 — a .616 winning percentage.  Teams that win 38 games would have a .633 winning percentage. The Astros (.660), Dodgers (.654) and Yankees (.636) were the only teams that did better than that over a 162-game season last year.  Of course, a 60-game season is much different.  A 60-game sample  We looked at the division leaders after 60 games last season. The Dodgers were the best of the bunch at 41-19. Here’s a look at the division leaders’ records after 60 games last season:  TeamWLDodgers4119Yankees3822Astros4020Twins4020Brewers3426Braves3327The average record among those teams? Again, we’re looking at 38-22.   Room for variation  Vegas, the full-season numbers and the 60-game sample all seem to agree. A team that wins 38 games should be able to claim its division in a 60-game season.  So, we’ll call 38 the magic number to essentially assure a postseason berth.  You can go a few games up or down to allow for variation, and that’s why that 40-20 vision is important in a 60-game season. Wild card teams can probably get in with 34 wins or fewer, but there are no guarantees in a 60-game format.   Win totals via Odds Shark Team2019 WINS2020 WINSLos Angeles Dodgers10637.5New York Yankees10337.5Houston Astros10735Minnesota Twins10134.5Atlanta Braves9734Tampa Bay Rays9634Washington Nationals9334Oakland Athletics9733.5St. Louis Cardinals9132.5Chicago Cubs8432Cleveland Indians9332Los Angeles Angels7232New York Mets8632Boston Red Sox8431.5Chicago White Sox7231.5Cincinnati Reds7531.5Philadelphia Phillies8131.5Arizona Diamondbacks8531Milwaukee Brewers8931San Diego Padres7031Texas Rangers7829.5Toronto Blue Jays6728Colorado Rockies7127.5Pittsburgh Pirates6925.5San Francisco Giants7725.5Seattle Mariners6825Kansas City Royals5924.5Miami Marlins5724.5Baltimore Orioles5421.5Detroit Tigers4721.5 MLB’s 60-game season should create some wild playoff races within the six divisions. But what’s the magic number to claim a division title? That will be interesting to find out, but teams should have 40-20 vision heading into the season. That is, 40 wins should be more than enough to win a division, while a wild card berth should fall at least several wins below that.Let’s take a closer look at what should be the goal for major league teams in 2020.last_img read more