April 20 2001 Timothy Balker a pilot from Embry

first_imgApril 20, 2001Timothy Balker, a pilot from Embry-Riddle Aeronautical University in Prescotthad to make an emergency landing on the north side of the Arcosanti dirt road.He was flying a Cessna 178 heading for Phoenix, when a leak in an oil line obscuredvisibility and forced him to land on our property. [Photos by Jeff Manta] View all the images after the landing:last_img

Just 11 of Turkish internet users watched Netflix

first_imgJust 11% of Turkish internet users watched Netflix in the past month compared to a 13-country average of 24% of viewers, according to Ampere Analysis.The research firm described Netflix viewing levels as “low” in the country, despite a prolific level of online video viewing on smartphones.YouTube topped the list of video services used in the past month by Turkish consumers, with 76% of Turkish internet users having watched videos on the service compared to an all countries’ average of 66%.More than half of Turkish web users had also watched video on Facebook in the past month, compared to an average across the other markets surveyed of 32%.Viewing of Twitter’s live-streaming service, Periscope, stood at 15% in Turkey compared to a 13-country average of 3%.“The prevalence of strong local streaming services from telcos, widespread usage of social video, and the strength and importance of locally-produced content, means that services such as Netflix and Amazon have a lot of work to do to gain traction among Turkish consumers,” said Ampere Analysis research director, Richard Broughton.Overall, Ampere found that 76% of respondents in Turkey view online video on their smartphones compared to an all country average of 58%. Some 43% of Turks were found to view online video daily on their smartphones, significantly ahead of the global average of just 25%.However, Turkish nationals were also found to be much less likely than average to have games consoles, Blu-ray players and OTT streaming devices such as Apple TV or Chromecast.“Turkish internet users enjoy accessing online video content and are using a variety of devices to enable them to do so throughout the day,” said Broughton.“With 97% of Turkish internet users living in a household in which someone owns a smartphone, smartphones are the clear ‘go to’ device for accessing online video content. But we also see an unusually high level of viewing via the computer – largely reflecting lower uptake of other connected device types such as streaming boxes or sticks.”The research was based on a survey of 26,000 respondents in 13 countries around the world: the US, UK, France, Germany, Spain, Italy, Netherlands, Denmark, Sweden, Brazil, Poland, Turkey and Saudi Arabia.Earlier this month, Ampere reported that Saudi Arabian internet users watched more TV and video online than people in any other country, with 87% of Saudi viewers watching online video content on their smartphones.last_img read more

BBC Studios premium British drama channel BBC Fi

first_imgBBC Studios’ premium British drama channel, BBC First, is due to launch in Poland in October.Sean Bean in BrokenThe linear TV channel will replace BBC HD and be available in the country via DTH satellite, cable and IPTV providers alongside BBC Brit, BBC Earth, BBC Lifestyle, CBeebies and BBC World News.The launch will make the full BBC channel portfolio available in Poland from the first time from October 26, with BBC First to be available with English and Polish subtitles.The channel will launch with a number of acclaimed series, including territory premieres of Sean Bean drama Broken and psychological thriller Paula. It will also air crime series Unforgotten and all new series of Doctor Who.“We’re living through a golden era of British drama with outstanding talent producing some of the very best television in the world,” said Jacek Koskowski, general manager and vice president for Poland, BBC Studios.“Increasing the drama hours on BBC HD was integral to that channel’s recent growth and now we are going further by bringing viewers even more of what they want. Coupled with the addition of Polish and English subtitles for the first time, I’m delighted to be introducing a dedicated premium drama channel to Poland.”BBC First is also available in Australia, South Africa, Benelux and the Middle East.last_img read more

Oil 8509 9239 9574

first_imgOil85.0992.3995.74 Rock & Stock StatsLast Silver Stocks (SIL)24.1224.4524.15 One Month Ago TSX Venture1,300.921,327.811,621.00 Gold Junior Stocks (GDXJ)23.9423.8831.44 TSX (Toronto Stock Exchange)12,196.8012,273.5712,156.22 Copper3.473.733.44center_img Silver32.1633.8734.58 One Year Ago Dear Reader,Well, just as Doug Casey predicted, Obama won the US election. I wouldn’t make too much of Doug’s successful prediction, as he’s the first to say that these two Obama victories are the only presidential elections he’s predicted correctly.More to the point is the joke going around about two guys watching the election results in a bar, when Obama’s victory is announced. One guy groans: “Four more years!” The other guy cries: “Four more beers!”What’s interesting about this to us is that it reflects investor sentiment. The markets reacted strongly to the election, clearly showing that most investors think another Obama term is bad for the economy. It was striking to see gold and the Dow move so sharply in opposite directions.RealityThe reality – according to Doug and the Casey Brain Trust – is that neither likely winner could stop the train wreck ahead for the economy, so the outcome really didn’t matter.Sure, Obama wasted no time in talking about raising taxes on the rich, which surely only added to investors’ certainty that the president will make things worse. But Romney could have pushed the US into a war much faster, and that would need to be paid for – not that drone-happy Obama is a dove himself.Again, the reality is that even if the differences in rhetoric between Obama and Romney were real, they simply don’t matter compared to the world of hurt pending after decades of mismanagement of the US economy and the post-2008 panic. The stampede has taken the US in completely the wrong direction (dousing the debt bonfire with more easy money), as it has in Europe and Asia as well.All I can really add to this is to remind people of Doug’s mantra for this cycle: buy gold for prudence, gold stocks and other “crisis investing” stocks to speculate for profit, and internationalize yourself to diversify your political risk.PerceptionThat said, perception does move investors, and prices are fixed at the margins, especially during a market mania, which, by definition, divorces prices from underlying value.In this context, the post-electoral perception of increased economic risk is obviously bullish for the financial safe haven of gold. This on top of the probable seasonal increase in gold prices this winter is highly bullish for precious metals stocks in the months ahead – miners and explorers alike. And if we see any black swans alighting during this time, fear and greed could both drive the masses into the only investing sector that offers security and profits.That would be powerful indeed, and we’d see a market mania for the record books.But even if no major black swans upset the house of cards our politicians are desperately trying to hold together amidst a hurricane with an unlimited flow of money-glue… well, there’s still the unlimited flow of money-glue and its necessary consequences, which are bullish for all things real, especially precious metals.There’s also the looming US “fiscal cliff” and all the media circus around the political grandstanding we’ll see in the weeks and months ahead. Indeed, it’s already started. Among the things at stake are sunsetting tax cuts, the lapse of which would hit many middle-class families hard, not just “the rich.” The rhetorical slugfest ahead and its impact on investor perceptions promises to keep markets fear-dominated and volatile. And that too is very bullish for precious metals in the near term.Investors already active in the precious-metals sector seem to realize much of this already. Share prices for good companies that have not run out of cash are up, money is becoming available for project financing, and mergers and acquisitions activity has started heating up again.I’m happy to say that our readers who acted on our recommendations to buy during last summer’s Shopping Season are profiting already, and poised to profit more in the months ahead.What To DoGiven these circumstances, the odds dictate the following general strategies:If you’re long, do not let greed get the better of you: take profits when you have them. You can redeploy them into more stocks if you’re extremely bullish and don’t mind losing your gains, should the market turn in an unexpected way. Or take them out of the game – use them to buy some real asset you want or need. Or whatever else suits your fancy. Just don’t get cocky. Yes, we expect things to continue going up for some time, but no one can say what will be with certainty.If you’re not long, it is not too late. There are great deals out there that have still not rebounded much from last summer’s lows, as well as others that have, but which have material, value-adding developments coming soon. Plus, a rising tide lifts all ships –at least the ones without holes in their hulls.In short, if you’re an investor who’s unhappy with the way the US election turned out, just remember what to do when life hands you lemons – make lemonade. We don’t call the shots, but we can sure do our best to profit and provide for our loved ones based on the trends we see developing.No whining.That’s the investor’s equivalent of being a deer caught in headlights. The deer are not actually caught – if they’d just keep going, they’d almost never get hit at all.The cure for post-election blues is action. If you agree with my analysis above, you know what to do. If you don’t agree, that’s fine – take action based on whatever you see the trends to be. Either course has risks and may or may not work out, but sitting in the headlights is the worst thing you can do.Sincerely,Louis JamesSenior Metals Investment StrategistCasey Research Gold Producers (GDX)50.6752.0860.69 Gold1,738.251,774.001,784.00 Gold and Silver HEADLINESShift in Miners’ Priorities: More Attention to Profit Growth (Ernst & Young)The recently released Mergers, Acquisitions and Capital Raising in the Mining and Metals Sector report by Ernst & Young shows that the overall value of deals completed in the first nine months of 2012 fell 43% year-to-year. The fall is attributed to “turbulent and changing environment of cost inflation, slowing economic growth, heightened geopolitical risk and volatile prices.” The report reveals that these hard conditions have led to a shift in mining companies’ priorities from “growth for growth’s sake” to growth in profits, which includes cost control, credit quality, and focus on shareholder returns.The report says this now means that deals will be more focused on acquisitions that “bring more than market share – such as improved productivity, lower average costs, or improved asset utilization.”This actually sounds quite healthy, in our view. It’s about time more companies focused on good management, and did not just assume higher commodity prices would cover sloppy or reckless policies.Chinese Jewelers Go West for Growth (Reuters)Chinese jewelers are shifting their focus to smaller, inland cities, urged by growing consumer demand for gold. Industry insider Leon Zhao, a consulting director from research firm Frost & Sullivan’s China operations, says “third- and fourth-tier cities are going to be the main engine of China’s jeweler market.” His company believes such cities will account for more than 40% of the country’s total jewelry market by 2015, up from 34% in 2010 and 29% in 2006.Some regional jewelers have already noticed that “in the past two to three years retail outlets in tier three and tier four and in central and western parts of the country have performed better than those in coastal cities.”This trend suggests that China’s gold market is far from being saturated. There are numerous smaller cities that have big potential to consume more gold in the near future, as wealth and spending power increases in these less-developed areas.last_img read more

If you have any interest at all in making the kind

first_img If you have any interest at all in making the kind of money most investors only dream about, you simply have to speculate in today’s junior precious metals explorers.  Historically, they reverse with a vengeance after the kind of extreme overbought conditions we’re seeing today… like Conquistador, which rose 1,874% in 1996… Silverado Mines, which shot up 3,988.5% in 1980, or Golden Scepter, which skyrocketed 7,650% in 1983. To show you why the precious metals sector is on the cusp of rewarding bold speculators with similar gains and how to position yourself to maximize this opportunity, Casey Research is hosting Downturn Millionaires.  This must-see web video event features contrarian investing legends Doug Casey and Rick Rule, who have leveraged beaten-down markets to fortunes multiple times for themselves and their clients… John Mauldin, chairman of Mauldin Economics … Bill Bonner, founder of Agora Publishing… and Casey Research Chief Metals and Mining Investment Strategist Louis James, who will reveal what to look for in a junior mining company, as well as one company with millions of proven ounces of gold in the ground that’s selling at a huge discount. Downturn Millionaires premiers at 2 p.m. on April 8 – to reserve your spot, click here now. Natural resource investors have experienced a tough year. The price of gold bullion has fallen from its 2011 highs and the prices of even good junior companies have been slashed to as little as half of their former valuations. All the more reason to start returning broker phone calls according to David Galland, Casey Research managing director, speaking on the Friday eve of the airing of a webinar he is moderating, featuring some of the biggest names in the industry. The webinar, “Downturn Millionaire: How to Make a Fortune in Beaten-Down Markets,” features Casey Research Founder Doug Casey, Sprott Global Resource Investments Founder Rick Rule, International Speculator Editor Louis James, “Endgame” Author John Mauldin and Diary of a Rogue Economist Editor Bill Bonner. In this interview with The Gold Report, Galland shares the motivation behind assembling this all-star cast for a golden wake-up call. The Gold Report: You are moderating a webinar for Casey Research titled “Downturn Millionaire: How to Make a Fortune in Beaten-Down Markets.” This is going to air on Monday, April 8. It’s an interesting title considering the current state of the precious metals market. Gold hasn’t even flirted with $1,900/ounce ($1,900/oz) since 2011 and dropped below $1,600/oz. Silver fell from $43/oz that same year to below $30/oz. Will this conference deliver the painful message that the bull market is over or do you have some good news for listeners? David Galland: We have some good news. The genesis of the webinar is somewhat interesting. Long-term friend Rick Rule, founder and chairman of Sprott Global Resource Investments Ltd., sent an e-mail saying, “Guys, this is a real market capitulation and one of those rare opportunities to make serious money on the rebound.” The proverbial light went off in our collective heads because we, too, have seen this sort of extreme opportunity several times during our careers. And so we scrambled to pull this webinar together in about a week to help make our subscribers and friends aware of the importance of the market capitulation and how to take full advantage. Simply, this is one of those rare moments when absolutely no one wants anything to do with gold stocks, even though gold bullion itself really hasn’t sold off all that much compared to the gold stocks, which are off by as much as 50%. The overarching purpose of the webinar, therefore, is to serve as a gut check and to help people focus on the opportunity. After all, the global demand for minerals is only going to continue to grow, and the role of precious metals is especially important given the complete lack of monetary and fiscal restraint on the part of the U.S. and other large governments. The role of gold and silver is certainly not over, which points to a huge opportunity because the tremendous apathy and capitulation in the gold share market has knocked even the best companies flat on their backs. TGR: The demand argument makes sense, but were the smart people in this group able to come up with the reason why the stocks are doing so poorly compared to the bullion? DG: We discussed the stocks in depth, starting with the macro-picture for precious metals, and then, by extension, why people want to own the stocks. The speakers had some great insights about why we’ve gotten to this point. Then they focused on what they see ahead for the sector and specific ways to profit as the market bounces back. TGR: One of the featured speakers is Doug Casey, chairman of Casey Research. When we interviewed him in January for “The World According to Doug Casey,” he said “speculation is capitalizing on politically caused distortions in the marketplace.” We’ve had years of quantitative easing, but none of the inflation he predicted. Is the government winning? Is that answered in the webinar? DG: I wouldn’t say we’ve had none of the inflation. The government does its very best to cover it up but we all know that prices have gone up considerably on a lot of things. Look at the basics—foodstuffs, energy and so forth. Are governments winning? No, they are just digging themselves and their respective economies a deeper and deeper hole. That said, you could certainly say that at this stage of the battle, people seem to have forgotten that there’s a connection between money printing and inflation. It is baffling because deconstructing the Great German Inflation and other inflations around the world, it was clear to everyone that money printing was the primary culprit. Yet people seem to have once again forgotten that connection. The faculty in this webinar address the questions of where the inflation is heading, why hasn’t it shown up and what can we expect when we see it. The consensus view among the faculty was that we’re looking at inflation rates in the high double digits and maybe worse within the foreseeable future, maybe not tomorrow, but it will come. Governments around the world seem to think that their economies are like washing machines that can be fixed with a bit of tinkering, but they’ll have serious trouble turning off the money printing machines. Social promises have been made, hundreds of millions of people now rely on governments for the bulk of their sustenance. Yet it’s important to remember that governments don’t actually make anything, except maybe wars. Where is the money going to come from for all these social programs? It’s going to be magically whipped up out of thin air essentially. That will have an effect on the purchasing power of the currency units already in circulation, and it will have a positive effect on the prices of tangibles, most importantly gold and silver. TGR: Participant Bill Bonner, who is the editor of The Diary of a Rogue Economist, also watches macrotrends. Does he see any end to the emergency-of-the-week theme playing out on the global stage? And does he have any suggestions for how investors can protect themselves from the fallout? DG: Bill completely understands the role that gold plays in preserving personal net worth, but doesn’t usually discuss gold shares per se. Even so, in our webinar he said something that really got my attention, “The time to buy these shares is when nobody wants to own them, when even you don’t want to own them.” That struck home with me because I’ve been investing in this market since the 1970s, and long ago I learned that the time you really want to back up the truck is when you have exactly the kind of bombed out markets that we have today. As Bill spoke, it really resonated because I, too, have been ducking calls from my broker, and I have a lot of respect for my broker. Worst of all, my broker is calling me offering me financings on great companies that come with five-year warrants, which is a very rare thing and only seen in periods of complete capitulation. But I didn’t want to take the guy’s calls because of the same mistake a lot of people are making at this point, which is just to assume that the market is dead forever when, in fact, that’s very much not the case. TGR: So when David’s scared, that’s the time to buy. Is that what you’re saying? DG: Well, not so much scared. I just didn’t want to hear about the sector anymore. Listening to this webinar inspired me to spend time looking at stocks of companies that I know have great projects, and great management and cash in the bank. Universally, these great companies have sold off by 50-60% or more. Yet, there is nothing wrong with these companies other than this panic out of the risk-on trades in the junior resource sector. That was a real wake up call. TGR: Webinar speaker John Mauldin, author of Thoughts from the Frontline, predicted, in a November interview with us, “John Mauldin’s Roadmap to Surviving the Fiscal Cliff,” that politicians would find a way around the fiscal cliff that was looming at that time, but he warned that the economy would be in for a bumpy ride. In this webinar, did he have any predictions for when or how things would get better? DG: John jokes that even as a relative pessimist, he looks like an optimist when in the company of the Casey Research team. John still thinks there is the possibility of a political solution to the economic crisis. If there is, I haven’t seen it, and nothing on the horizon looks like it’s going to happen as far as I can see. Despite his cautious optimism, John was absolutely in sync with the rest of the speakers’ opinions about the great contrarian opportunity in gold and the gold share market, an opportunity that most people will miss, but shouldn’t. TGR: Another speaker, International Speculator Editor Louis James, stressed the importance of thinking long term when we interviewed him last September for the article “How Investors Can Protect Themselves in a Politicized Economy.” He said the junior market was looking “bottomish” and it looked like a good time to buy. Will he be mentioning what companies he likes in the webinar? DG: He talks about a couple of companies he likes as examples. He’s also quite adamant about the criteria that people should use in deciding what precious metals shares belong in their portfolio and what shares people should be selling now. The reality is that a good number of these companies will not survive this downturn. If you’re sitting on a company with no cash in the bank, an only so-so project and average management, there’s a reasonable chance it’s going to go to $0 even though it may have already gone down by 50%. In the webinar, Louis covers the specific aspects of companies you want to own in your portfolio and the ones you should lose. It’s an important message because these things are, as Doug Casey likes to say, not family heirlooms but burning matches. And the ones that aren’t going to make it just aren’t going to make it. You have to come to that reality. But the good news is that by rotating into the certain winners you can claw back pretty quickly when the market sentiment shifts, as it most certainly will. TGR: Another one of the webinar speakers, Rick Rule, is a very popular expert with The Gold Reportreaders. When he spoke to our president, Karen Roche, last November for an article titled “Be a Risk Manager, Not a Reward Chaser,” he called gold “catastrophe insurance.” Does he have any specific advice for how investors should adjust their portfolios in a downturn? DG: I would say similar to Louis, his message is very clear. There are definitely companies that aren’t going to make it, and then there are companies that are going to make it and make it in a very big way. It was interesting because I’ve known Rick for a couple of decades now and I have seen him give a lot of presentations, but he was very vocal in pointing to an urgency in this market that most people are missing. Rick, Louis, Doug and all of the people on this webinar are really on the same page about this. Investors need a wakeup call. They need to really be paying attention at this moment because it’s one of those rare, once-in-a-generation opportunities to, as John Mauldin says, get in front of a bubble. We’ve seen this before. We saw this in July 1982, another classic capitulation with gold falling from over $800/oz in 1980 to below $350/oz. As you might imagine, the gold shares were completely sold off with the volume on the Canadian stock exchanges falling to next to nothing. But then there were a couple of discoveries in the Hemlo district of Canada, coinciding with a rally in gold, and the market skyrocketed. One of the companies involved in a Hemlo discovery, Golden Sceptre, went from a low of $0.41/share up to $31/share in about a year. Another, Goliath Gold, went from $0.45/share in March 1982 to $32/share in March 1983, an increase of over 7,000%. That sort of opportunity is pretty much only available following periods of market capitulation such as we are experiencing today. People have forsaken reason, and they don’t want to know about gold stocks. That alone should point the way to a classic contrarian opportunity where pretty much everybody who is going to sell has sold, leaving only one way to move—up—for the companies with the right combination of attributes to survive. TGR: So as painful as this has been for all of us over the last couple of years, after listening to these speakers, are you ready to say you welcome a down market for the opportunity it affords? DG: Absolutely. And as I said, it was a complete wakeup call for me. Until participating in the webinar, I had completely stopped paying attention to the sector. Now I am completely re-engaged and talking to my broker again. TGR: Thank you for taking the time to talk to us. DG: It was nice to be with you.last_img read more

New law cracks down on right to use cash

first_img New law cracks down on right to use cash The U.S. government is trying to restrict your access to cash. But not for the reason you think… According to leaked evidence it’s much, much worse. Insuring themselves against “black swan” events, but not investing with the hope of profiting from them, Fixed Income – Historically, bonds make up this asset class. At one time, bonds (AAA municipal bonds) represented as much as 40% of my net investible worth. My strategy was always to hold until maturity and buy them in “ladders,” replacing them when they matured. But I haven’t bought them since the rates dropped below 4.5% and have sold some I didn’t like much. Today, they represent about 5% of my net investible wealth. I also own an annuity and a life insurance product. These are not the typical insurance products. Most annuities and life insurance products are very expensive and very complicated. You have to be very careful with those. Editor’s Note: Last Tuesday, Mark appeared on a special live webinar to discuss his experience with using options (to date, he’s generated over $282,000 in instant cash payouts over the last three years). To watch the replay of this event—and learn in detail how this technique works—click here. Rental Real Estate – Next to business ventures, income-producing property investments have been the largest contributor to my wealth-building success. I invest for the income and see appreciation as a bonus. As with insurance products, real estate investing can be tricky for the inexperienced investor. Most mainstream real estate advice is bad. But if you do it properly—focusing on income—this asset class will do huge work for your portfolio. Editor’s Note: Can you get rich investing in stocks and bonds? Palm Beach Research Group founder Mark Ford has more insight into this question than most. Although he’s not an investment analyst, he’s worked in the financial publishing industry for over 30 years. He’s also built dozens of businesses from scratch…creating millions of dollars of wealth in the process. In short, Mark knows more about building wealth than just about anyone. In today’s Weekend Edition, Mark explains nine steps he is personally taking right now to grow and keep his money. By Mark Morgan Ford I am not an investment professional. I have never made any money managing other people’s money. I went from rags to riches the old-fashioned way: working hard and then investing my income as carefully as I could. Because I’d done well on my own, I never considered seeking financial advice. Then a funny thing happened. I woke up one day with the thought that I should have a “professional” manage some of my money. I interviewed two firms. One was a boutique business based in New York City that a friend recommended. The other was a private banking facility for one of the world’s largest brokerages. The boutique firm was happy to take $100,000 of my money to get started. The other company wanted a minimum of $10 million. They both had fancy offices and pretty marketing brochures. But such frills scare me. They make me think, “Gee, these guys must be charging their customers a lot to afford all this stuff.” My trepidations notwithstanding, I worked with both of them for about six months. I answered their questions about my tolerance for risk (little to none). I listened to their presentations. And then I did something that I bet few of their clients ever do. I started asking them questions. And I kept pushing them to explain why I should believe that they could help me become wealthier. What I got instead was clever circumlocution. A financially sophisticated version of what you’d expect from your teenage son if you pestered him about why he didn’t come home until four in the morning. Those discussions convinced me that these guys could not manage my money better than I had been managing it. To be fair, they certainly knew more about investment products than I did. But they didn’t know more about how to become wealthy. These guys were smart. They had graduate degrees from great schools. They spoke eloquently. They seemed so…so…inside the game. I wanted them to be better than me. I really did. But they really didn’t seem to care whether their services would make me richer or poorer. The contracts they wanted me to sign were going to put money in their pockets regardless. That didn’t feel right. In the end, I told both of my elite financial planners to take a hike. And I went back to managing my money myself. Seeing Only 20% of the Big Picture The investment advisory industry is a huge multibillion-dollar business based on hard work, clever thinking, and sophisticated algorithms. But also on one teensy-weensy lie. The lie is that you can grow wealthy investing in stocks and bonds. It’s not a big, black lie. But the unfortunate truth is the financial establishment rarely looks beyond stocks and bonds. And if you think about it, why would it want to? It makes its money by ushering you from one “hot” stock or “amazing” fund to the next. Wall Street wants you to think the stock (and sometimes the bond) markets are the only places you can make money. And because they know that you have heard that “diversification of assets” is good, they give you the illusion of diversification by having your stock portfolio invested in businesses that are “diversified” into manufacturing, retail, global trade, natural resources, etc. This is, as I said, an illusion. At the end of the day, it’s all invested in stocks or stock derivatives. The result? More risk and less potential wealth gain for you. So start by deconstructing the little lie. Building wealth involves much more than just investing in stocks and bonds. Most rich people get that way by consistently doing the following nine things: Giving top priority to increasing their net investible income, not maximizing returns, Options – Although my cardinal rule is not to invest in something I don’t understand, my colleague, Tom Dyson, found a way to trade options that I both understand and also believe in. Like real estate and insurance products, most options strategies are speculations. I’d advise against them. But the way Tom taught me to do it, selling puts on legacy-type stocks, has worked very well for me. In fact, over eight years of testing, it’s proven successful 96.2% of the time. If you’re interested in a free, three-part training series he’s currently running on this type of options trading, I recommend clicking here. Spending less as a percentage of net income as it grows so they can save more, Investing in safe real estate—i.e., income-producing properties, Recommended Links Jim Rickards Issues “Critical Warning #3″… Jim Rickards just issued a new critical market update. You need to check this out… Jim’s issued this kind of update only twice before in recent history… Both times were about massive changes in the markets. And this change is even BIGGER… See this very short video by clicking here. Investing in stocks and bonds with discipline—i.e., without expecting to get returns that are much higher than market averages, And keeping a substantial store of cash to be used when “cash becomes king.” As you can see, investing in stocks and bonds is only one of nine strategies you must follow to become rich, but that was the only one that the two money management firms I tried cared about. Direct Investments in Entrepreneurial Businesses – This is, by far, the investment class that has given me the best results. If you do this right, you can expect terrific, steady income and the potential for enormous growth. The trick here is to invest only in companies you understand and have some control over. Owning tangible, portable, and non-reportable assets as a reserve that can be tapped into at opportune moments, Cash – I call this a “Cash Opportunity Fund.” You keep a store of money you add to every year. That way, when the crash comes, you can use this fund to swoop in and buy a bunch of great assets at bargain prices. Understanding debt and using it occasionally and strategically to build wealth, — Chaos Hedges – This asset class is not, for me, an investment. It is, as the name implies, protection from times of turbulence—a market crash, bankruptcy, lawsuits, etc. In this class I include gold, silver, and platinum coins (bullion and one or two “rare” types). I bought all I needed when gold was trading at about $400 an ounce. It’s gone up and down since then but at today’s prices it looks good again. Collectibles – This is a category of investing that you will probably not be interested in, unless you want to enrich not just your net worth but your experience of living each and every day for the rest of your life. My preferred collectible is fine art and first-edition books, but you can invest in anything from baseball cards to vintage cars to surfboards. How to Ensure Financial Growth and Security So if you can’t reasonably expect to get rich with just stocks and bonds, what can you do? You can model your investing behavior on the behaviors that have been proven, time and time again, to actually work. I’m talking about asset allocation. Asset allocation is the process by which you spread your wealth across different sorts of investments. You might think that something so dull as asset allocation could not possibly be that important in acquiring wealth, but numerous studies have shown that it may be the most important factor. (These studies can be found here.) Because of an early financial disaster, I became an emotionally compulsive diversifier of practically every dollar I could save, putting some of it in bonds, some in stocks, some in cash, some in real estate, and so on. Over the years I have made hundreds of individual financial decisions—buy this, sell that. Some of them were quite good, a few of them were quite bad, and most of them were in-between. And yet, overall, my net worth had increased considerably and consistently, without any down years, for more than 30 years. I could see very clearly that this was not due to the particular buy/sell decisions that accounted for this good fortune. It was the general decisions about asset allocation that paid off. Since I discovered this, I have been telling my readers about my own asset allocation decisions every year. Not because I think my portfolio is the best possible exemplum of diversification, but just to illustrate my belief that one needs to go well beyond some combination of stocks, bonds, and cash to win at the wealth-building game. My yearly report is reasonably detailed, but the following will give you a bird’s eye view of what I do. Stocks – I have several stock portfolios: one that you might call “legacy” stocks, one that I call “performance stocks,” and a third group that includes what would conventionally be called “growth” and “speculative” stocks. The lion’s share (maybe 80% to 90%) of my stock money is in the legacy stocks: a handful of big, dividend-giving companies that I’m happy to keep on a “forever” basis. A smaller percentage is in dividend-giving companies with growth potential. And a tiny percentage are speculations—stocks I’m quite sure I’ll lose all my money on but I want to own them just for fun. – Investing directly in private enterprises and other “outside Wall Street” opportunities,last_img read more

Advanced spectroscopic techniques used to prepare characterize major degradation products of pralatrexate

first_img Source:https://benthamscience.com/ Reviewed by James Ives, M.Psych. (Editor)Dec 13 2018The major degradation products of pralatrexate drug product formed under hydrolytic and light stress conditions were identified, synthesized, and characterized using advanced spectroscopic techniques such as NMR, HR-MS, and IR. For quantification of related compounds including the degradation products of pralatrexate drug product a stability indicating HPLC method was developed and validated as per ICH guidelines.Pralatrexate is an antineoplastic folate analog which is chemically named as (2S)-2-[[4-[(1RS)-1-[(2,4-diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino] pentanedioic acid. Pralatrexate injection is a preservative-free, sterile, isotonic, non-pyrogenic clear yellow aqueous solution for intravenous administration. Chemical stability is an important product quality attribute of the pharmaceutical molecule that affects the safety, quality and efficacy of drug product. The information on the stability of a molecule helps in developing proper formulation, container-closure as well as storage conditions and shelf life. To understand the stability of molecule it is necessary to study degradation profile of a product. The samples generated from forced degradation can help in establishing stability indicating method and also degradation path way of product which helps to predict degradation products arise during accelerated and long term storage conditions. Forced degradation study for drug product is also very important for identifying as well as to know the nature of the degradation products (hydrolytic/oxidation/ heat) and to elucidate the structure of the drug products generated during stress study. To understand the degradation pathway of products an efficient analytical method is required which should be able to detect the impurities generated from stress conditions. High Performance Liquid Chromatography and HR-MS are the best tools to study the impurity profile of degradation products. It is also important to develop a sensitive HPLC method which should be able to detect and quantify the impurities at lower level. To know the detection level of degradation products in a HPLC method, pure forms of impurities are required. Four major degradation products pralatrexate finished product were synthesized and characterized by NMR, FTIR and HR-MS spectroscopic techniques. A sensitive and stability indicating HPLC method was developed and validated for quantification of pralatrexate and degradation products as well related compounds of pralatrexate in pralatrexate liquid formulation.last_img read more

FSU study breaks new ground in the battle against malignant pediatric brain

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jan 30 2019Scientists are making important progress in the battle against a class of devilishly complex human pediatric brain cancers thanks to a new study from a team of Florida State University students and faculty.Among young children, there’s no brain tumor more common than medulloblastoma. But no specific and effective therapy yet exists for this dangerous disease. Instead, doctors are forced to resort to onerous and invasive treatments like surgery, radiation and chemotherapy, often at the expense of the child’s quality of life.Medulloblastoma, which is divided into four subgroups, is partially caused when a mutation occurs in the “driver genes” that either promote or suppress cancerous tumor growth. These mutations can be inherited, sporadic or environmentally induced, but once they appear, they increase the risk for the unfettered and abnormal cell division that leads to malignant tumors.A team of FSU researchers, led by Professor of Chemistry and Biochemistry Qing-Xiang “Amy” Sang, was interested in learning more about these mutations. Using data from the Catalogue of Somatic Mutations in Cancer, they identified a series of cancer-causing driver gene mutations and discovered that medulloblastoma is perhaps an even more dynamic and variable tumor than expected.Their findings were published in the Journal of Cancer.”Most cancer is quite heterogeneous, but medulloblastoma is specifically very heterogeneous,” Sang said. “If you look at the driver gene mutation, it’s not as if the majority of medulloblastoma cases have the same mutation. In reality, 5 percent may have one mutation, 3 percent may have another mutation and a small percentage may have other mutations. That’s why you cannot treat it as one disease.”Using advanced bioinformatics tools, the team was able to pinpoint which driver gene mutations were occurring in which medulloblastoma subgroups. In some cases, they found that mutations once considered specific to one particular subgroup were causing significant disruption in sister subgroups as well. While these findings were surprising, they were exactly the kind of counterintuitive details the team was searching for.”What we focused on specifically in this paper are the driver genes that we weren’t expecting to see,” said study co-author Mayassa Bou Dargham, a doctoral candidate at FSU. “We wanted to focus on some infrequent events and stress the heterogeneity of medulloblastoma tumors themselves. That’s important whenever we’re using targeted therapy for different subgroups.”Related StoriesStudy provides new insight into longitudinal decline in brain network integrity associated with agingNew therapy shows promise in preventing brain damage after traumatic brain injuryDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustMedulloblastoma’s heterogeneity makes it an exceptionally difficult cancer to characterize and treat. But with a more comprehensive and nuanced understanding of which mutations happen where and when — and which mutations might defy broadly accepted definitions — researchers will be better equipped to identify opportunities for targeted, individualized treatments.”For medulloblastoma, a more personalized approach will have to happen,” said Jack Robbins, who was an undergraduate when he co-authored the study. “The goal we should be striving for is more MATCH-based trials in which we use molecular targets found from these different panels of driver events. These driver events extend past the genomic code and into epigenetic mechanisms that need to be further studied and assessed in the clinic to identify candidate therapies. We can hopefully give those therapies to patients who aren’t responding to the standard of care treatments.”The next step in developing those therapies is to develop credible laboratory models of human medulloblastoma tumor subgroups. These models, researchers say, will be important evaluative tools in the search for potential therapeutics.The ultimate goal is a regimen of targeted therapies that avoid causing undue burden to vulnerable pediatric patients.”Children with cancer often receive very toxic, harsh and invasive treatments,” Sang said. “If we can avoid those harsh treatments and develop safer and more efficacious therapies, then the patients’ outcomes and their quality of life will be much improved.”Cross-disciplinary collaborations may be a key to finding more effective therapies for this intractable disease. But another crucial key, Sang said, will be innovative ideas from a new generation of ambitious researchers.She said this paper demonstrates the instrumental and field-defining contributions of student scientists. In addition to Robbins, former FSU undergraduates Kevin Sanchez and Matthew Rosen co-authored the paper.”I’m very fortunate to be at FSU,” she said. “The success of our undergraduates demonstrates that FSU is a great university for both top graduate and undergraduate students. I want to emphasize the students’ contribution, especially with this paper. It’s special.” Source:http://www.fsu.edu/last_img read more

Leisuretime sitting but not sitting at work linked with greater risk of

first_imgOur findings show that how you spend your time outside of work may matter more when it comes to heart health. Even if you have a job that requires you to sit for long periods of time, replacing the time you spend sitting at home with strenuous exercise could reduce your risk of heart disease and death.”Study author Keith M. Diaz, PhD, assistant professor of behavioral medicine at Columbia University Vagelos College of Physicians and Surgeons and a certified exercise physiologist Reviewed by Alina Shrourou, B.Sc. (Editor)Jun 27 2019Sitting for long periods of time has been linked to increased risk of cardiovascular disease and early death, but a new study suggests that not all types of sitting are equally unhealthy.The study, led by researchers at Columbia University Vagelos College of Physicians and Surgeons, found that leisure-time sitting (while watching TV)–but not sitting at work–was associated with a greater risk of heart disease and death among the study’s more than 3,500 participants. The study also found that moderate-to-vigorous exercise may reduce or eliminate the harmful effects of sedentary television watching. The study was published online today in the Journal of the American Heart Association.BackgroundA growing body of research shows that people who are sedentary–especially those who sit for long, uninterrupted periods of time–have a higher risk of cardiovascular disease and death.But most previous studies did not follow people over time, making it difficult to draw conclusions about the relationship between sedentary behavior and health risk. These studies have included mainly people of European descent rather than African Americans, a group that has a higher risk of heart disease compared with whites. Previous studies also measured physical activity using an activity monitor, which is unable to distinguish between different types of sedentary behavior.What the study foundThe new study followed 3,592 people, all African Americans, living in Jackson, Miss., for almost 8.5 years. The participants reported how much time they typically spent sitting while watching TV and during work. They also reported how much time they spent exercising in their down time.The participants who had logged the most TV-viewing hours (4 or more hours a day) had a 50% greater risk of cardiovascular events and death compared to those who watched the least amount of TV (less than 2 hours a day).Related StoriesRNA-binding protein SRSF3 appears to be key factor for proper heart contraction, survivalWeightlifting is better for the heart than cardioSmoking triples the risk of death from cardiovascular diseaseIn contrast, those who sat the most at work had the same health risks as those who sat the least.Even for the most dedicated TV watchers, moderate to vigorous physical activity–such as walking briskly or doing aerobic exercise–reduced the risk of heart attacks, stroke, or death. No increased risk of heart attack, stroke, or death was seen in people who watched TV for 4 or more hours a day and engaged in 150 minutes or more of exercise a week.Why does the type of sitting matter?In a previous study, Diaz found that excessive sitting is linked to worse health outcomes, and even more so when sitting occurs in lengthy, uninterrupted bouts.”It may be that most people tend to watch television for hours without moving, while most workers get up from their desk frequently,” Diaz says. “The combination of eating a large meal such as dinner and then sitting for hours could also be particularly harmful.””More research is needed, but it’s possible that just taking a short break from your TV time and going for a walk may be enough to offset the harm of leisure-time sitting,” adds Diaz. “Almost any type of exercise that gets you breathing harder and your heart beating faster may be beneficial.”And although occupational sitting was less problematic, Diaz notes that the same approach to movement applies at work. “We recognize that it isn’t easy for some workers, like truck drivers, to take breaks from sitting, but everyone else should make a regular habit of getting up from their desks. For those who can’t, our findings show that what you do outside of work may be what really counts.”The researchers suspect that the study’s findings may be applicable to anyone who is sedentary, even though the study focused on African Americans.What’s nextIn future studies, Diaz will examine why TV watching may be the most harmful sedentary behavior and whether the timing of sedentary behavior around dinner time could be a contributing factor. Source:Columbia University Irving Medical CenterJournal reference:Diaz, K.M. et al. (2019) Types of Sedentary Behavior and Risk of Cardiovascular Events and Mortality in Blacks: The Jackson Heart Study. Journal of the American Heart Association. doi.org/10.1161/JAHA.118.010406.last_img read more

Not just for kids a leap for seniors at Vegas tech show

first_img Sensors help smartphones keep eye on solo seniors “We can detect falls, but the predictive aspect of it is to monitor changes in behavior so we can alert family members,” Familier said.Also launched at CES was the Addison Virtual Caregiver, a video-based assistant with a female avatar which can converse, offer reminders on medication and detect potential health issues.With the data gathered from the device, “we can classify people as high-risk or low-risk fallers,” said David Keeley, research director for Addison parent firm SameDay Security.”We can predict the rate of functional decline.” Artificial musclesFor those with mobility issues, the California startup Seismic unveiled its wearable tech body suit which can augment a user’s muscles and help them maintain posture.The “core wellness suit,” which weighs under five pounds and can be worn under street clothes, has robotic components that provide up to 30 watts of power to each hip and the lower back to support sitting, standing, lifting, or carrying—similar to an exoskeleton but without the bulk.Sarah Thomas, a Seismic vice president and advisor to tech startups, said the new product is designed not only for the elderly but for factory workers to ease fatigue and anyone with mobility issues.Thomas said tech products for seniors should not be “stigmatized” with unsightly products.”We should be designing with age in mind but without the ageist perspective,” Thomas told a CES panel. © 2019 AFP Explore further With artificial intelligence to detect falls, virtual reality to combat isolation and “powered” clothing to assist the incapacitated, the tech world is stepping up its effort to “disrupt” aging. Sarah Thomas (R) of California startup Seismic talks to the 2019 Consumer Electronics Show about “powered clothing” using robotic muscles to help people with fatigue and disabilities, as customer Bob Copani of San Francisco models the garment “You don’t need to wear anything, there are no cameras,” said Ofer Familier, head of business development for Vayyar.The company, which makes a range of sensor equipment, says Walabot can detect subtle changes in gait, movement or breathing which could signal a risk of a fall or other problem. At the Consumer Electronics Show this week in Las Vegas, exhibitors were showcasing new ways to help the elderly remain independent, mentally fit and connected.Some systems took a page from the gaming world of youngsters to help seniors “travel” to new places and connect with loved ones.”Everyone knows seniors get lonely but that isolation can also lead to a lot of medical problems, including the acceleration of dementia,” said Kyle Rand, founder and chief executive of Rendever, a startup which works with assisted living homes to give seniors a way to virtually visit remote locations.”They can stand atop the Eiffel Tower, they can go on an African safari, or revisit their childhood home.”Rendever was launched in the Washington DC tech incubator created by the American Association of Retired Persons (AARP), which in recent years has been funding efforts to develop new technologies for seniors.In the consumer space from the AARP incubator, Alcove VR enables seniors to be part of a virtual world with loved ones who may be far away. Pillo, an all-in-one pill dispenser, personal digital assistant, and communication device is displayed at the 2019 Consumer Electronics Show David Keeley of SameDay Security debuts the Addison Virtual Caregiver system at the Consumer Electronics Show in Las Vegas, a digital assistant designed to monitor seniors living alone Alicia Mangram, a Phoenix-based trauma surgeon who is an advisor to Addison, said the system can be useful in helping seniors remain independent.”Right now when we send people home (from a hospital) we don’t know what happens to them,” Mangram said. “This allows us to check on them.”Florida-based startup CarePredict exhibited its system based on a wearable band that helps monitor seniors in assisted living facilities.”We can passively and unobtrusively monitor the daily activities of seniors, and our predictive tools can help identify if they are at risk of falls, depression, malnutrition or urinary tract infections,” said CarePredict’s Jerry Wilmink.Tech firms see a promising market in these kinds of devices, with public attention focused by the Apple Watch’s feature of fall detection.According to research firm eMarketer, Americans of age 55 and older are the fastest-growing group of electronic wearable users in the US, largely due to the devices’ enhanced health features. “You can step into a virtual living room (with a friend or family member and just hang out,” said Cezara Windrem, the AARP product manager for Alcove.Alcove was launched this week as a free application on Oculus, the Facebook-owned virtual reality unit.The AARP exhibit also included VRHealth, which offers cognitive behavioral therapy using virtual reality, and Pillo, a device which serves as a personal assistant and medication dispenser focused on health for seniors.Virtual caregiversOther exhibitors showcased technology that could help seniors remain in their homes, and give family members peace of mind by monitoring their condition, in some cases using predictive analytics to determine if they are at risk.Walabot, a wall-mounted monitoring system developed by the Israeli startup Vayyar, uses radio waves and three-dimensional imaging to keep tabs on seniors living alone. The Walabot fall detection device for seniors from Israeli startup Vayyar is displayed at the 2019 Consumer Electronics Show This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Not just for kids: a leap for seniors at Vegas tech show (2019, January 11) retrieved 17 July 2019 from https://phys.org/news/2019-01-kids-seniors-vegas-tech.html Jerry Wilmink of CarePredict holds a wearable tech band that can help monitor seniors in assisted living and help predict falls or other health issues at the 2019 Consumer Electronics Showlast_img read more