How To Make Product Lifecycle Management (PLM) A Strategic Asset

first_imgGuest author Kevin Prendeville is a global managing director with Accenture’s Product Lifecycle Services practice.The tables have turned on many large high-tech companies – market leaders have become followers while followers have become leaders. What’s behind the seismic shift? The ability of those former followers to leverage investments in product development processes to deliver more innovative and successful products. These processes, known as Product Lifecycle Management (PLM), extend from idea gener¬ation through product launch to product retirement.An analysis by Accenture has found that large high-tech companies can spend $1 billion or more per year on Product Lifecycle Management in hopes of substantially boosting revenues and cutting costs. But Accenture also found that many C-suite executives view PLM as the engineering department’s black box – a critical enterprise business process poorly understood, measured or managed.Today’s competitive business environment requires that top management see PLM as a strategic corporate asset, a cross-functional, enterprise-wide business discipline that augments innovation, helps drive revenue growth, and reduces costs of everything from engineering rework to regulatory compliance.What Is Product Lifecycle Management (PLM)?PLM integrates a multitude of critical cross-functional activities, such as:product strategyportfolio managementproduct managementidea and requirements gatheringproduct designproduct engineeringproduct validation and complianceproduct costingproduct qualitydirect material sourcingmanufacturingafter-market services product retirementPLM capabilities support PLM activities to drive activities, decisions and data within the end-to-end PLM process. Examples includeintellectual property managementproduct structure and reuseengineering changesstage-gate approvalsideas and requirementssoftware configurationquality tests and defectsproduct costsdevelopment project statusFor global enterprises to maximize the business impact of PLM, they need to examine two dimensions: effectiveness and efficiency.Large high-tech companies are making substantial investments – often 5% to 25% or more of revenue – in PLM. But according to Accenture’s analysis, nearly half of PLM ends up wasted on products that do not meet market needs or timing. High-tech enterprises have thousands of highly skilled and well-paid designers, scientists and engineers working inside global PLM processes across hundreds of current and future products. But due to lack of central coordination, prioritization and integration of processes, systems and data, they’re often working on essentially useless or redundant tasks. That means there’s a huge opportunity for improvement.Technology can help improve PLM – if it’s implemented with an integrated plan focused on a distinct business process. Most global companies have deeply fragmented PLM systems comprising 20 or more applications. PLM software vendors provide powerful and field-tested applications – but not the kind of end-to-end business process coverage available in leading customer relationship management (CRM) and enterprise resource planning (ERP) applications. Most high-tech companies use three or more PLM vendors to span the various PLM capability areas.Four Ways To Improve PLMTrue enterprise PLM requires building an end-to-end framework that spans multiple solutions and accom¬modates business processes and data from marketing, design, product portfolio management and more. A one-size-fits-all answer does not exist, but Accenture has identified four best practices to get the most out PLM:Step 1. Create an enterprise-wide framework to define PLM capabilities. Define what is and is not PLM, then formally break down and re-evaluate current PLM capabilities. Review all processes, applications, metrics, organization and data that underpin product development process flow from initial concept to product retirement. Then examine the performance and maturity of each as objectively as possible. High-performance businesses structure PLM as a hierarchy of capabilities that span the process, represent various organizations and competencies, and connect all corners of the PLM landscape with each another. Most companies that go through this exercise are surprised by how disjointed and fragmented their overall PLM approaches are and by how many gaps and redundancies they uncover. And they are often alarmed to find how few metrics and how little docu¬mentation supports their PLM activities.Step 2. Link the PLM framework’s capabilities to key corporate and product priorities. Settle on five-to-ten business metrics that track the effectiveness and efficiency of innovation and product development outputs, transcending any one department or function. They might relate to pipeline throughput, cost of engineering, reuse of platforms or components or resource use. For instance, if plans call for more new products to be developed in lower-cost countries, the PLM framework would link that objective to the corresponding capabilities and metrics.Step 3. Use the prioritized PLM framework As An investment planning tool. It is relatively straightforward to turn the results of these exercises into a powerful tool for ongoing planning activities. The organization’s varied constituents can more easily analyze trade-offs, guide investments in product development improvement projects, and measure the impact of those projects over time. For example, one high-technology company used this framework to concentrate its future PLM focus and investment to improve software product development processes rather than mechanical design. Basically, the firm chose to improve the productivity of its thousands of software designers instead of its hundreds of mechanical designers.Step 4. Establish a group to own and update the PLM framework and corporate roadmap. As with CRM, ERP and supply chain management, there has to be a single, formal organization to advance and support PLM. That organization should have visible, unambiguous sponsorship from a senior executive. This helps ensure PLM becomes part of the company’s innovation fabric rather than a one-time project.Three PLM Success StoriesUsing these best practices, several high-tech companies have made significant progress with their PLM strategies:1. One version of the truth. A provider of servers and storage equipment re-designed its business processes to better leverage PLM technologies. The firm created “one version of the truth” for a single engineering change process for all its hardware products including several from large acquisitions.2. Integrating hardware and software. A provider of electronic gaming equipment developed new processes, data models and a central application to manage the relationship between its hardware designs and corresponding software designs, as they evolved through development and change processes.3. Increasing re-use. A global consumer electronics company implemented a streamlined portal and graphic user interface – providing a fast and visual way for designers and engineers to search, find and re-use components, solutions and information stored in its PLM databases.The good news is there are many cross-industry cases proving the merits of improving PLM. The better news is that many industries have already blazed PLM trails, providing proven strategies, lessons learned and methodologies for high-tech companies to leverage.Image courtesy of Shutterstock. Tags:#business software#enterprise IT#Software Related Posts Cognitive Automation is the Immediate Future of… Massive Non-Desk Workforce is an Opportunity fo…center_img kevin prendeville IT + Project Management: A Love Affair 3 Areas of Your Business that Need Tech Nowlast_img read more

Expert Advice Series: TRICARE® ECHO – Applied Behavioral Analysis (ABA)

first_imgAdvice: The ACD policy requires that prior to coverage of ABA, the beneficiary must be diagnosed with ASD using DSM-5 criteria and issued a referral for ABA by a TRICARE-authorized Physician-Primary Care Manager (P-PCM) or by a specialized ASD diagnosing provider whether they work in the purchased care or direct care system.  The medical record and the referral must contain documentation of the Autism Spectrum Disorder (ASD) diagnosis and documentation of co-morbid psychiatric and medical disorders.  We also require that ASD symptom severity be documented on the referral, but plan to delete this requirement from the referral itself in the next policy update which we expect sometime in FY 2017.Referrals made for TRICARE Prime beneficiaries from the Direct Care system (the MTF) providers are made electronically in Composite Health Care System (CHCS). These electronic referrals are sent to the regional managed care support contractor for processing. The regional contractor then sends an authorization letter specifying the ABA provider/practice information and the authorization number to each beneficiary.  The Active Duty Family Member (ADFM) parent/caregiver is to call the phone number of the ABA practice on the authorization letter to schedule the appointment for ABA. If the provider cannot see the patient within 28 days, then the ADFM parent/caregiver should directly telephone the regional contractor at the phone number specified in the authorization letter for help getting an appointment with another ABA provider able to see the beneficiary within the 28 day access standard.For Purchased Care under TRICARE Prime, each regional contractor, in this case UHC, defines their referral requirements. If UHC requires the referral be written on a paper prescription pad, then this is the process that must be followed.  Under TRICARE Standard plans, referrals per se are not used, but rather a prior authorization process if followed. Each regional contractor specifies the process per contractual requirement.  The process may involve filling out a regional contractor online form requesting authorization, faxing in this information on a form or telephoning the regional contractor to request for authorization.  Regardless of each regional contractor’s process, prior authorization is required for ABA services under the ACD. Each authorization is for six months.I hope this answers your question.  Each regional contractor is available per the phone numbers provided in the presentation to assist family members with the referrals and authorizations. Please encourage the families you assist to call the regional contractor whenever there are problems or challenges accessing ABA through the ACD as we do not want beneficiaries to wait to access ABA services. This MFLN-Military Caregiving concentration blog post was published on September 16, 2016. In a recent webinar entitled “TRICARE® Extended Care Health Option (ECHO)” participants were able to gather more information about the supplemental services for active duty family members with qualifying mental and physical disabilities provided through TRICARE® ECHO.Question: I had a couple questions regarding the Applied Behavioral Analysis (ABA) referral process and what type of medical equipment is covered by ECHO and what is not. There seems to be a lack of communication between the child’s Primary Care Manager (PCM) and United Health Care (UHC) when sending in a referral for ABA therapy.  Does the ECHO Case Manager have the correct verbiage and time line to share with the families on what the PCM needs to state on the referral prior to sending to UHC to begin the process for ABA services?  A lot of my clients have shared with me that if the PCM does not write the referral on a prescription pad and if the correct verbiage is not written on the referral  that UHC will kick the referral back.  This causes a lot of confusion for the clients and the process to begin the services for their child with Autism takes longer.Also, is there a list of medical equipment that ECHO does cover when Tri-care does not?  Such as hearing aids, wheel chairs etc.center_img Expert: Theresa A. Hart, RNC MS, Nurse Consultant/Program Manager, Perinatal, Pediatrics and Special Medical Programs Defense Health Agency Clinical Support DivisionFor more advice from Ms. Hart, watch and listen to the professional development training on TRICARE® Extended Care Health Option (ECHO) to learn about the ECHO program.The new blog series provides monthly advice from subject matter experts on issues surrounding military caregiving for service providers and families. We take questions and concerns from military helping professionals and families and provide the necessary feedback from credible experts in the field of study. Whether you are a provider or a caregiver, what questions do you have? We want to hear from you.last_img read more

75-year-old patient knifes Pune doctor

first_imgA 75-year-old patient knifed a doctor at Sinhagad Speciality Hospital Monday evening following suspicions that his medical bill had been inflated. A case has been lodged against the patient at Abhiruchi police station.Maruti Shirwale, who was admitted last week following a severe bout of asthma, attacked Dr. Santosh Awari when he came to check on him during his evening rounds. The doctor sustained injuries in his abdomen. Shirwale was reportedly recovering from alcoholism and exhibiting withdrawal symptoms.Hospital authorities said that the patient’s relatives allegedly told him that the doctor had inflated his bill. Dr. Awari said the bill had not been prepared as the patient required further hospitalisation.Dr. Awari said, “This is a startling and rather bizarre incident. No mention of any bill has been made to his kin. Following the assault, I have told them that the patient can be shifted to Navle Hospital if they have any apprehensions about the expenditure.”Footage of the incident retrieved from CCTV cameras went viral. It shows the doctor attending to another patient before approaching Shirwale’s bed. Shirwale is seen grabbing a knife hidden under his pillow and attacking Dr. Awari. The patient starts uttering expletives at teh hospital staff attempting to restrain him after the doctor escapes.Dr. Sangeeta Waghmode, secretary, Sinhagad Road Doctors’ Association, said: “It appears that the patient was lying in wait for the doctor. The incident is alarming and shows that the medical fraternity is vulnerable to caprice of patients.”last_img read more

Norman Wilners Top 10 movies of 2016

first_img LEAVE A REPLY Cancel replyLog in to leave a comment Facebook Twitter 2. Paterson (D: Jim Jarmusch)If not for the stunning Moonlight, this would have easily topped my list. Jarmusch’s latest is a deadpan, down-to-earth character study about a week in the life of a quiet New Jersey bus driver (Adam Driver) who’s also a poet who views his modest environs with a sense of wonder and actively folds his life into his work. The pace may be sleepy, but Paterson is alive to every interaction, every possibility. I can’t think of another recent movie that plays quite like it, mixing gentle humanity and absurd comedy with profundity and even awe. (Opens February 3.) Login/Register With: 1. Moonlight (D: Barry Jenkins)Jenkins’s long-overdue follow-up to 2008’s Medicine For Melancholy traces a decade and a half in the life of an African-American kid in Florida in three distinct movements. Moonlight shows us how small moments of kindness or cruelty can profoundly affect the human heart, how people are always more complex than you think they are and how cinema is unmatched at communicating ideas and feeling. In a year marked by contempt and rage, Moonlight dares to hope empathy will save us. Advertisementcenter_img Mary Cybulski Advertisement Advertisement 3. cameraperson (D: Kirsten Johnson)The best documentary of the year is an essay film constructed from footage shot by documentary cinematographer Johnson over the decade and a half she worked on movies like The Invisible War, Citizenfour, Fahrenheit 9/11 and Trapped. Interweaving outtakes from those films with her own home videos … Don’t miss Paterson, starring Adam Driver and Golshifteh Farahani, when it’s released in early February.last_img read more

Ohio State mens swimming takes 2nd Michigan 1st in Big Ten Championships

Michigan stayed the course after taking an early first-place lead in the men’s swimming and diving Big Ten Championships in Iowa City, Iowa, Saturday night. Ohio State finished second in the four-day event with 552.5 team points, 186 points behind the leader. Indiana and Minnesota tallied 549 and 403, respectively. The Buckeyes were led by title-winners junior Jason Schnur, in the 50 and 100 freestyles, and senior Andrew Elliott, in the 200 backstroke. Schnur and Elliott broke school records in the preliminaries Saturday morning. The 200 breaststroke was dominated by Indiana’s sophomore Cody Miller with a 1:54.07 swim. Miller broke his own record which gave him the title last year. Freshman Chris Cowley was the only Buckeye to score points in that event, placing 16th. OSU sophomores Shane Miszkiel and Christian Holstein took first and second place, respectively, in the one-meter dive Friday night. Miszkiel’s dive marked his first Big Ten title. Michigan took the 400 individual medley, 100 butterfly and 200 freestyle to expand its lead on OSU. The 200 freestyle relay team also posted a record-breaking time of 1:17.70 Thursday with performances from Schnur, senior Lincoln Fahrbach, junior Zach Holmes and junior Zach Birnbrich. Although the OSU relay team’s performance was enough to land in the school’s history books, Iowa placed first in the event, edging the Buckeyes by .09 seconds. Sophomore Alex Miller and senior Brent Hitchcock placed seventh and eighth, respectively, in the 500 freestyle competition, while junior Luke Stirton finished ninth with a time of 4:20.63. In the opening day of competition, the Buckeyes swam into third in the 200 medley relay behind Michigan and Penn State. OSU and Michigan were separated by .04 seconds. OSU improved from its third place performance last season. In 2010, they claimed the Big Ten title for the first time since 1956. The Buckeyes return to the pool Sunday in the Last Ditch NCAA Qualifier at the McCorkle Aquatic Pavilion. The meet will give participating athletes a final opportunity to qualify for the 2012 NCAA Championships held March 22-24 in Seattle, Wash. read more

Ziggos shares were priced at €1850 when the Dutc

first_imgZiggo’s shares were priced at €18.50 when the Dutch cable operator started trading on the Amsterdam Stock Exchange this morning, resulting in a market capitalisation of €3.7 billion.The IPO consists of 43,478,260 ordinary shares, 21.7% of the operator’s total shares. The total offering size amounts to approximately €804 million.last_img

KFC Has a New Nail Polish That Tastes Like Chicken Start Up

first_imgStart Up Your Day Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Opinions expressed by Entrepreneur contributors are their own. Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. 1 min read Enroll Now for $5 Lindsay Friedman Staff writer. Frequently covers franchise news and food trends. KFC Has a New Nail Polish That Tastes Like Chicken — Start Up Your Day Roundup Add to Queue Image credit: Settawat Udom | Shutterstock Looking for the latest headlines in small business, innovation and tech? Our Start Up Your Day recaps are posted every morning to keep you current.Planned. Tesla plans 500,000 cars for 2018. Inclusivity. Uber will bring its new accessible ride services to Chicago starting this month, according to The Chicago Tribune.Under the knife. This robot surgeon sewed up a pig’s insides.Don’t mess with mama. In honor of Mother’s Day this weekend, Facebook Messenger will adorn your chats with flowers.A new day. Burger King will launch a new breakfast sandwich, the Egg-Normous Burrito.  Finger-licking good. KFC seems to have taken its slogan seriously after releasing its own nail polish. It’s supposed to taste like chicken. May 5, 2016 –shares Next Article last_img read more

Larsen Toubro Infotech Eyes AI ML and Analytics Market with Lymbycs Acquisition

first_imgLarsen & Toubro Infotech Eyes AI ML and Analytics Market with Lymbyc’s Acquisition Sudipto Ghosh6 days agoJuly 17, 2019 AcquisitionAIanalyticsLTILymbycMarketing Technology NewsNewsSaasVirtual Analyst Previous ArticleSesame Software Partners with Snowflake on Integration/Data Warehouse SolutionNext ArticleEsker Partners, Invests in B/2BNOW in Support of SAP S/4HANA Cloud ERP Acquisition to enhance Larsen & Toubro Infotech ‘s Mosaic platform with Deep Learning, NLP, and Visualization capabilitiesLarsen & Toubro Infotech Ltd., a global technology Consulting and Digital Solutions company, is acquiring Lymbyc. Lymbyc is a specialist AI, Machine Learning, and Advanced Analytics company. The acquisition further strengthens LTI’s fast-growing Digital and Analytics offerings.Larsen & Toubro Infotech will Compete in AI-Based Cloud Computing MarketWith growing dependence on data, global enterprises need to be better at data discovery, agile analytics, and the ability to process large datasets. Lymbyc’s expertise in these spheres will enhance Larsen & Toubro Infotech’s Mosaic platform to provide differentiated analytics solutions in a SaaS model.At the time of this announcement, Sanjay Jalona, Chief Executive Officer and Managing Director, LTI, said —“We believe self-service capabilities for AI and advanced analytics will be the next wave of disruption in the marketplace, and Lymbyc brings this capability to our Mosaic platform. Leni by Lymbyc is an industry-agnostic platform that solves business user’s need for experience, speed, and comprehension. I welcome Lymbyc’s experienced management team and all its employees to the LTI family.”Satyakam Mohanty, Founder, and CEO, Lymbyc said, “As a strategic business partner of LTI during last year, we have seen first hand how LTI is leading data and digital transformation agenda for its clients. With AI becoming increasingly mainstream, we are excited to join hands with LTI and to help a larger and richer set of clients. Leni, our AI-based Virtual Analyst, is perfectly suited to deliver better value to business users and maximize their information and analytics investments.”Getting Leni to Work for Larsen & Toubro Infotech CustomersLymbyc is headquartered in Bengaluru, India. Since inception in 2012, the company has acquired customers in the USA, UK, Africa, and India. The company is well recognized for its unique capabilities in analytics and data-sciences space. Lymbyc was also recognized and featured in Gartner’s Market Guide for Data Analytics and Service Providers 2019.Marketing Technology News: Progress Named a Leader in the New 2019 Gartner Magic Quadrant for Multiexperience Development PlatformsThe core of Lymbyc’s capabilities are centered around a proprietary product, Leni. Lymbyc offers two products:Leni as a serviceLeni as an APICurrently, Leni solves for the entire spectrum of descriptive to predictive Business Insights, leveraging Deep Learning, Natural Language Processing, Data Visualization, and Predictive Analytics. Leni is a Virtual Analyst that allows users to conversationally access information and insights.Leni ServiceMarketing Technology News: WebCEO, the Agency Oriented Marketing Platform, Launches a New Local SEO ModuleLTI and Lymbyc have been strategic partners for the last one year, and have collaborated to deliver unique solutions to several leading global enterprises.Lymbyc is the fifth acquisition by LTI since the company got listed in 2016. Earlier this year, the company acquired Ruletronics, a boutique Pega Consulting company, and N+P (NEILSEN+PARTNER), a Temenos Wealthsuite specialist.Marketing Technology News: Introducing Shutterstock Elements, Thousands of Cinema-Grade Video Effects for Filmmakerslast_img read more

Genetic testing and breakthrough therapies may transform diagnosis care of neuromuscular disease

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 31 2018A new report funded by the Muscular Dystrophy Association (MDA) and released by the IQVIA Institute for Human Data Science indicates that genetic testing and breakthrough therapies will transform the diagnosis and care of neuromuscular disease within the next decade. The report, “Understanding Neuromuscular Disease Care,” highlights current gaps in care and opportunities to optimize care and accelerate the emergence of new therapies. Insights gained from a survey of health care professionals focused on the care of patients with neuromuscular disease are also included.Neuromuscular diseases encompass a broad group of disorders that collectively impact an estimated 250,000 patients and their caregivers in the United States alone. Although these diseases are rare and treatment options are currently limited, the financial impact is high. IQVIA’s report reveals total annual costs across all neuromuscular patients exceed $46 billion. The diagnostic odyssey can often take upwards of a year, although improvements in the speed, price and comprehensiveness of available genetic testing are accelerating the process. The report sheds light on the role data will play in revolutionizing the importance of early genetic screening, intervention and treatment, including through the newborn screening public health program, which has enormous implications on time to diagnosis and intervention.”MDA is in the best possible position to transform the lives of people with neuromuscular disease,” says MDA President and Chief Executive Officer Lynn O’Connor Vos. “As the umbrella organization for more than 40 neuromuscular diseases, and with multidisciplinary clinics providing best in class care at more than 150 of the nation’s top medical institutions, we are galvanizing both industry and the research arena to develop better care and more cures.”Through its comprehensive data hub, MOVR (NeuroMuscular ObserVational Research), MDA is playing a pivotal role in the advancement of research and care in neuromuscular disease. MOVR rolled out in 2018 and will become fully implemented at 50 MDA Care Centers in 2019 to improve the ability for researchers and health care providers to identify precision medicine treatments, enhancing options for care.Related StoriesResearch sheds light on sun-induced DNA damage and repairLiving a healthy lifestyle may help offset genetic risk of dementiaFungal infection study identifies specific genetic vulnerability among Hmong people”The MOVR Data Hub will be extraordinarily powerful, enabling us to capture genome data, clinical data, professionally reported data and patient/family-reported data all in in one place,” says Dr. R. Rodney Howell, chairman of MDA’s Board of Directors. “The data from MOVR will provide benefits both in the present, identifying patients for treatments based on their genomic data, as well as in the future, as new treatment options become available. The study of the genomic data will identify important new genetic modifiers.”Other insights from the study: Source:http://www.mww.com/ “The rapid progress being made in improving patient care and outcomes through the combination of scientific breakthroughs and the development of secure, scalable cloud-based data hubs is remarkable,” says Murray Aitken, executive director of the IQVIA Institute for Human Data Science. “Expectations are high for advancing patient care and bringing disease-modifying therapies across a number of neuromuscular diseases to patients and their families. We are pleased to collaborate with MDA in undertaking research that highlights both the gaps in care and the opportunities to address them in the near-term.”center_img Treatment for neuromuscular disease is generally provided through a multidisciplinary care model, allowing patients to visit a range of specialists synchronously in a dedicated center. Care paradigms and provider treatment decisions may be inconsistent, reflecting the challenges of small patient populations, varied symptoms and a lack of official guidelines, particularly for many of the less prevalent diseases. Adopting technologies for remote appointments and real-time monitoring can improve care management by minimizing patient travel and increasing communication with health care providers. There is a need to develop innovative approaches to pricing and reimbursement to tackle access to care for patients. Psychological symptoms are an ongoing challenge, affecting 75 percent of patients and recognized by 90 percent of neuromuscular disease health care professionals as a high unmet need.last_img read more

Advanced spectroscopic techniques used to prepare characterize major degradation products of pralatrexate

first_img Source:https://benthamscience.com/ Reviewed by James Ives, M.Psych. (Editor)Dec 13 2018The major degradation products of pralatrexate drug product formed under hydrolytic and light stress conditions were identified, synthesized, and characterized using advanced spectroscopic techniques such as NMR, HR-MS, and IR. For quantification of related compounds including the degradation products of pralatrexate drug product a stability indicating HPLC method was developed and validated as per ICH guidelines.Pralatrexate is an antineoplastic folate analog which is chemically named as (2S)-2-[[4-[(1RS)-1-[(2,4-diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino] pentanedioic acid. Pralatrexate injection is a preservative-free, sterile, isotonic, non-pyrogenic clear yellow aqueous solution for intravenous administration. Chemical stability is an important product quality attribute of the pharmaceutical molecule that affects the safety, quality and efficacy of drug product. The information on the stability of a molecule helps in developing proper formulation, container-closure as well as storage conditions and shelf life. To understand the stability of molecule it is necessary to study degradation profile of a product. The samples generated from forced degradation can help in establishing stability indicating method and also degradation path way of product which helps to predict degradation products arise during accelerated and long term storage conditions. Forced degradation study for drug product is also very important for identifying as well as to know the nature of the degradation products (hydrolytic/oxidation/ heat) and to elucidate the structure of the drug products generated during stress study. To understand the degradation pathway of products an efficient analytical method is required which should be able to detect the impurities generated from stress conditions. High Performance Liquid Chromatography and HR-MS are the best tools to study the impurity profile of degradation products. It is also important to develop a sensitive HPLC method which should be able to detect and quantify the impurities at lower level. To know the detection level of degradation products in a HPLC method, pure forms of impurities are required. Four major degradation products pralatrexate finished product were synthesized and characterized by NMR, FTIR and HR-MS spectroscopic techniques. A sensitive and stability indicating HPLC method was developed and validated for quantification of pralatrexate and degradation products as well related compounds of pralatrexate in pralatrexate liquid formulation.last_img read more

New research lays out potential path for treatment of Huntingtons disease

Reviewed by James Ives, M.Psych. (Editor)Dec 14 2018New research gives scientists a clearer picture of what is happening in the brains of people with Huntington’s disease and lays out a potential path for treatment. The study, which appears today in the journal Cell Stem Cell, shows that support cells in the brain are key contributors to the disease.”Huntington’s is a complex disease that is characterized by the loss of multiple cell populations in the brain,” said neurologist Steve Goldman, M.D., Ph.D., the lead author of the study and the co-director of the Center for Translational Neuromedicine at the University of Rochester Medical Center (URMC). “These new findings help pinpoint how the genetic flaw in Huntington’s gives rise to glial cell dysfunction, which impairs the development and role of these cells, and ultimately the survival of neurons. While it has long been known that neuronal loss is responsible for the progressive behavioral, cognitive, and motor deterioration of the disease, these findings suggest that it’s glial dysfunction which is actually driving much of this process.”Huntington’s is a hereditary and fatal neurodegenerative disease characterized by the loss of medium spiny neurons, a nerve cell in the brain that plays a critical role in motor control. As the disease progresses over time and more of these cells die, the result is involuntary movements, problems with coordination, and cognitive decline, depression, and often psychosis. There is currently no way to slow or modify the progression of this disease.While the symptoms of the disease are the result of the loss of motor neurons, the new study adds to mounting evidence that the disease may be triggered by faulty glia, the brain’s primary support cells. These cells include oligodendrocytes – which produce the brain’s supply of myelin, an insulating substance that mediates communication between nerve cells – and astrocytes, which support the function of neurons and maintain the chemical balance necessary for nerve cells to communicate with their neighbors.Earlier clinical studies have hinted at the role of glial cells in the disease. MRI scans of patients with Huntington’s have shown myelin and white matter loss in the brain long before the symptoms of the disease appear.The new findings were made possible because of an advance made in Goldman’s lab, which enables researchers to study human glial cells in the brains of animals. Using embryonic stem cells obtained from individuals with the Huntington’s disease mutation, the researcher were able to reprogram these cells to become glial progenitors – the parent cell that gives rise to both astrocytes and oligodendrocytes. When these cells are transplanted into the brains of mice, they out-compete native cells and produce brains with human glia and animal neurons. This model has not only been used to study Huntington’s, but other diseases in which it is believe that glial cells play a role, including frontotemporal dementia and schizophrenia.Related StoriesNeural pathways explain the relationship between imagination and willingness to helpDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustAn active brain and body associated with reduced risk of dementiaIn 2016, Goldman’s lab found that when healthy human glial cells were transplanted into mice engineered to express the mutant Huntingtin gene – which typically show signs of Huntington’s disease and die at a young age – the progress of the disease was slowed. That research focused on astrocytes which, among other functions, serve as a buffer for potassium, which regulates the electrical signals that form at synapses, the points of connection between nerve cells. When astrocytes are not doing their job, as is the case in Huntington’s disease, the resulting chemical imbalance causes neurons to become overexcited and ultimately die. In those experiments, the new healthy human astrocytes restored normal neuronal activity and rescued nerve cells that might otherwise have perished.The new research gives scientists a more precise understanding of how the genetic flaws in people with the disease result in dysfunctional glial cells. Huntington’s is caused by a genetic mutation called a repeat expansion, or a stutter that results in duplicates of a small section of genetic code. The length of this repeat can dictate the age of onset and severity of the disease.Using cells derived from individuals with the Huntington’s mutation, researchers were able to identify a series of errors that impeded the transcription of genetic information into proteins that tell progenitor cells to become either oligodendrocytes or astrocytes. In Huntington’s disease these transcription errors impaired the creation of oligodendrocytes, and hence resulted in fewer cells able to make myelin, and similarly affected the production of astrocytes, which failed to mature properly and were unable to effectively regulate agents, such as potassium and glutamate, which are necessary for communication between nerve cells.The research suggests that viral vectors or gene editing techniques like CRSIPR could be employed to activate the transcription of these deficient glial genes. Goldman’s lab tested this approach in mutant Huntington mice, and found that forced expression of the genes restored myelination in the animals’ brains. The study also validated the lab’s earlier findings that placed glial cell dysfunction at the center of the disease and the concept that the most direct approach towards halting the progress of the disease might consist of replacing sick glial cells with healthy ones. Source:https://www.urmc.rochester.edu/news/story/5472/study-confirms-central-role-of-brains-support-cells-in-huntingtons-points-to-new-therapies.aspx read more

Targeting aging process itself can lead to better and more effective interventions

first_imgReviewed by James Ives, M.Psych. (Editor)Feb 11 2019Medical care for older adults has long focused on preventing and treating chronic diseases and the conditions that come with them. But now, geriatrics researchers and clinicians hope a new understanding–one honed at a prestigious conference hosted by the American Geriatrics Society (AGS) and the National Institute on Aging (NIA), with support from The John A. Hartford Foundation–can lead to better and more effective interventions by targeting the aging process itself rather than discrete conditions or concerns.”Aging is complex and varies from one person to the next, but there’s a growing body of evidence that aging itself is driven by interconnected biological factors we call ‘hallmarks’ or ‘pillars,'” said Christopher Carpenter, MD, MSc, FACEP, FAAEM, AGSF, one of the co-authors of a report on the conference. “We believe disrupting these hallmarks–which cover everything from the stability of our genes to ways our cells communicate–can contribute to chronic disease and frailty, which is why a better understanding of how they work is so important.”Convened in 2016 as the second conference in a three-part series for recipients of the NIA’s Grants for Early Medical/Surgical Specialists Transition into Aging Research (GEMSSTAR) program, the NIA “U13” conference brought together more than 100 scholars, researchers, leaders representing 19 medical specialties, and NIA representatives to stimulate research across the disciplines involved in high-quality, person-centered care. Conference findings, published in the Journal of the American Geriatrics Society (DOI: 10.1111/jgs.15788), detail how new methods of studying the older-adult population can reveal new tools and accelerate innovative treatments focused on big-picture outcomes important to people’s lives, such as function and independence.Rather than beginning with the discrete health conditions and concerns common among older adults, conference organizers took the unique approach of focusing on aging itself as a primary factor impacting multiple chronic diseases and the declining ability to rebound from health challenges (also known as “resilience”). In doing so, GEMSSTAR scholars advanced our understanding of the concept that targeting age-related mechanisms might delay, prevent, or even reverse geriatric syndromes, age-related chronic diseases, and declines in resilience. Conference sessions also focused on new methods and strategies for studying these aspects of aging, and reviewed the challenges of studying age when older people often have been excluded from medical research.Major themes that emerged from the conference include a need for increased attention to: * The study of our human population as it ages. Most clinical trials still look for people who are “ideal,” such as people who do not have chronic diseases. However, researchers now understand the importance of ensuring pragmatic clinical trials reflect the full spectrum of health for older adults, particularly those who are frail. These individuals often are the most likely to live with multiple chronic diseases, which can be treated best when we understand how medications and other interventions will affect “real” as opposed to “ideal” people. * The need for new tools to help older adults and caregivers adapt to changing health needs. Studying the biology of aging could yield even more approaches to aging-related disease prevention or treatment for geriatrics experts who will be needed in greater numbers as the world continues to age. For example, geriatrics health professionals are already adept at streamlining medication management for common conditions such as diabetes and high blood pressure. A better understanding of the interactions of resilience, metabolism, and inflammation with aging, however, could deepen these clinicians’ hypothesis that many common medicines prescribed for these conditions could play a role in supporting general health as we age. * The importance of accelerating how we translate research into promising clinical practice. Conference workshops also focused on ways to make aging research actionable for clinical studies and clinical practice. For example, suggestions included integrating aging concepts into research conducted by “subspecialists” in particular areas of medicine; creating a national, diverse “geroscience biobank” attuned to exploring multimorbidity and frailty in particular; incorporating “precision medicine” as a catalyst for individualized healthcare delivery; using existing databases like the Baltimore Study of Longitudinal Aging to forge collaborations and inform early-stage hypotheses; and creating a standardized “outcomes toolkit” to help bridge the gap between studies of aging and supports for our well-being as we age. * Supporting the future of aging research. As more and more people benefit from increased longevity, specialty clinician-investigators–so named for their expertise in caring for patients and researching how that care takes shape–must be empowered to contribute to the evolution of aging research. Collaboration will be particularly important, said Evan Hadley, MD, Director of the Division of Geriatrics and Clinical Gerontology at the NIA, in his closing remarks for the GEMSSTAR U13 conference. Dr. Hadley emphasized that partnering across disciplines previously seen as independent will be important to future progress, which is why the GEMSSTAR community offered such an important outlet for beginning these discussions. The NIA’s GEMSSTAR program awards support to early-career physicians trained in medical and surgical sub-specialties to conduct transdisciplinary aging research. The AGS serves as a central coordinating body for applicants in particular specialties (anesthesiology, emergency medicine, general surgery, gynecology, orthopedic surgery, physical medicine and rehabilitation, trauma surgery, urology, and vascular surgery) interested in applying for professional development support, and connects these awardees with their specialty societies. Additional funds support a Professional Development Plan to complement the “R03” research project.center_img Source:https://www.americangeriatrics.org/media-center/news/report-prestigious-nih-funded-conference-looks-biological-pillars-aging-betterlast_img read more

During bombings robots played key role for Austin police

The bomb squad received its first robot, which was a fraction of the size of its current models, about two decades ago. The squad is in the process of acquiring two new robots from Remotec. The new devices are Andros FX models, which cost roughly $300,000 each. One of those new models is expected to be delivered this week, Joseph said. The Andros FX has a number of upgrades, including eight tracked wheels that allow it to be more agile, along with a more versatile arm and camera.More than robotsFounded in the 1970s, the Austin police bomb squad consists of seven bomb technicians. The squad has three options when responding to a call about a suspicious item, Joseph said. The team can investigate using one of its technicians, who wear formidable protective gear suit when handling suspicious items, it can deploy a rope device or it can dispatch a robot, Joseph said.”For every incident we respond to, the first question we roll out is, ‘Do we need to do it remotely?'” Joseph said. “It could just be because we did the last two or three incidents a different way, I want to change my response time, or just in case somebody were monitoring how we are doing it. And it helps eliminate some complacency.”But the robots aren’t the department’s only important technology. As calls of suspicious packages flooded in, many of the items were examined using mobile X-ray devices from tech firm Nex-Ray. The devices include a roughly foot-long X-ray machine that takes an image of whatever is inside a package and mirrors it on a tablet.”These were invaluable,” Renfro said. “They were used in just about every single one of the (suspicious package) calls. They saved hours and hours of these (officers) going out to calls where they would have waited for a response from one of these big trucks.”‘A larger question’While law enforcement officials point to the benefits of using robots in a variety of scenarios, some in the community have questioned how the devices are used, said Luis Sentis, a University of Texas robotics professor who has worked as a NASA contractor.One of the main worries, Sentis said, is that advances in automation will one day make the robots police use too powerful. A highly publicized example of this concern came after Dallas police in July 2016 used a robot to deliver and detonate a bomb next to a shooter who had killed five police officers. While a grand jury ultimately ruled that the decision was justified, it raised questions about police use of technology.”This is part of a larger question about should we eventually let robots (operate) without the supervision of a person,” Sentis said. “We are engineers. We develop the technology with the hope that behavioral scientists, policymakers, etc. – they are going to create tunnels and decisions that will drive the engineering community the right way. Communities decide what is ethical or not. Regulators decide that.”Police robots shouldn’t ever be used without a human controlling their moves, Joseph said. But he disputed the notion that the devices are too powerful.”Our robots are pretty much remote-control cars. They don’t do anything automatically,” Joseph said. “I would have been really unhappy to approach one of those packages myself without a remote capability.”Every single time we roll that thing out of the door, we’re thankful we have it.”Even with Conditt dead, the threat of bombs is not over.Last Thursday, more than a week after the serial bombings came to an end, three additional suspicious packages were reported to police.The bomb squad was on guard again, with the robots ready to roll if needed. Citation: During bombings, robots played key role for Austin police (2018, April 6) retrieved 18 July 2019 from https://phys.org/news/2018-04-robots-key-role-austin-police.html ©2018 Austin American-Statesman, Texas Distributed by Tribune Content Agency, LLC. On the morning of March 21, a white Austin police bomb squad truck pulled out of an obscure city facility near Austin-Bergstrom International Airport and rolled north, toward Pflugerville. The truck had been used a handful times in the previous weeks as a serial package bomber spread fear through Central Texas, with five bombs that killed two people while injuring others, and a sixth bomb that was intercepted by officials.Inside the truck was one of the bomb squad’s most high-tech weapons: a squat, steel robot. Its mission: to search the Pflugerville home of the bomber, 23-year-old Mark Anthony Conditt, who hours earlier had blown himself up in Round Rock as law enforcement officials closed in on him. After Conditt’s death, the robot was used to explore his house to make sure it was safe for investigators to enter.”I don’t know that we could have gained entry into (Conditt’s) home safely without putting the robot in there first,” said Austin police Lt. Courtney Renfro of the bomb squad. “I would be hesitant to send my officers into one of these situations without the robot. I probably wouldn’t have in this situation.”As of last week, Austin police had received about 2,500 calls concerning suspicious packages since the bombings began March 2, Renfro said. The bomb squad was dispatched on more than 300 of those calls—and on seven of those calls, the robots were deployed.Even with that small number of deployments, the robots were a crucial resource during the bombings, Austin police officials say. The robots are only used when officers believe the highest risk exists, such as when searching Conditt’s home for explosives, said Jeff Joseph, one of the police bomb technicians.The Austin police bomb squad has four robots, though only its two newer models were used during the recent bombings.The robots are Andros HD-2 models from the Remotec division of tech company Northrop Grumman. They are roughly 4 feet long, 2 feet wide and 2 feet tall. Moving around on four tracked wheels, they can travel about 3.5 miles per hour. The robots are equipped with an extension arm that has a clamp for grabbing and searching items, a rotating surveillance camera and front and rear articulators, or short legs, that allow it to climb stairs. The HD-2 models are lighter—260 pounds—than their older counterparts. Explore further Killer robot used by Dallas police opens ethical debate This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Not just for kids a leap for seniors at Vegas tech show

first_img Sensors help smartphones keep eye on solo seniors “We can detect falls, but the predictive aspect of it is to monitor changes in behavior so we can alert family members,” Familier said.Also launched at CES was the Addison Virtual Caregiver, a video-based assistant with a female avatar which can converse, offer reminders on medication and detect potential health issues.With the data gathered from the device, “we can classify people as high-risk or low-risk fallers,” said David Keeley, research director for Addison parent firm SameDay Security.”We can predict the rate of functional decline.” Artificial musclesFor those with mobility issues, the California startup Seismic unveiled its wearable tech body suit which can augment a user’s muscles and help them maintain posture.The “core wellness suit,” which weighs under five pounds and can be worn under street clothes, has robotic components that provide up to 30 watts of power to each hip and the lower back to support sitting, standing, lifting, or carrying—similar to an exoskeleton but without the bulk.Sarah Thomas, a Seismic vice president and advisor to tech startups, said the new product is designed not only for the elderly but for factory workers to ease fatigue and anyone with mobility issues.Thomas said tech products for seniors should not be “stigmatized” with unsightly products.”We should be designing with age in mind but without the ageist perspective,” Thomas told a CES panel. © 2019 AFP Explore further With artificial intelligence to detect falls, virtual reality to combat isolation and “powered” clothing to assist the incapacitated, the tech world is stepping up its effort to “disrupt” aging. Sarah Thomas (R) of California startup Seismic talks to the 2019 Consumer Electronics Show about “powered clothing” using robotic muscles to help people with fatigue and disabilities, as customer Bob Copani of San Francisco models the garment “You don’t need to wear anything, there are no cameras,” said Ofer Familier, head of business development for Vayyar.The company, which makes a range of sensor equipment, says Walabot can detect subtle changes in gait, movement or breathing which could signal a risk of a fall or other problem. At the Consumer Electronics Show this week in Las Vegas, exhibitors were showcasing new ways to help the elderly remain independent, mentally fit and connected.Some systems took a page from the gaming world of youngsters to help seniors “travel” to new places and connect with loved ones.”Everyone knows seniors get lonely but that isolation can also lead to a lot of medical problems, including the acceleration of dementia,” said Kyle Rand, founder and chief executive of Rendever, a startup which works with assisted living homes to give seniors a way to virtually visit remote locations.”They can stand atop the Eiffel Tower, they can go on an African safari, or revisit their childhood home.”Rendever was launched in the Washington DC tech incubator created by the American Association of Retired Persons (AARP), which in recent years has been funding efforts to develop new technologies for seniors.In the consumer space from the AARP incubator, Alcove VR enables seniors to be part of a virtual world with loved ones who may be far away. Pillo, an all-in-one pill dispenser, personal digital assistant, and communication device is displayed at the 2019 Consumer Electronics Show David Keeley of SameDay Security debuts the Addison Virtual Caregiver system at the Consumer Electronics Show in Las Vegas, a digital assistant designed to monitor seniors living alone Alicia Mangram, a Phoenix-based trauma surgeon who is an advisor to Addison, said the system can be useful in helping seniors remain independent.”Right now when we send people home (from a hospital) we don’t know what happens to them,” Mangram said. “This allows us to check on them.”Florida-based startup CarePredict exhibited its system based on a wearable band that helps monitor seniors in assisted living facilities.”We can passively and unobtrusively monitor the daily activities of seniors, and our predictive tools can help identify if they are at risk of falls, depression, malnutrition or urinary tract infections,” said CarePredict’s Jerry Wilmink.Tech firms see a promising market in these kinds of devices, with public attention focused by the Apple Watch’s feature of fall detection.According to research firm eMarketer, Americans of age 55 and older are the fastest-growing group of electronic wearable users in the US, largely due to the devices’ enhanced health features. “You can step into a virtual living room (with a friend or family member and just hang out,” said Cezara Windrem, the AARP product manager for Alcove.Alcove was launched this week as a free application on Oculus, the Facebook-owned virtual reality unit.The AARP exhibit also included VRHealth, which offers cognitive behavioral therapy using virtual reality, and Pillo, a device which serves as a personal assistant and medication dispenser focused on health for seniors.Virtual caregiversOther exhibitors showcased technology that could help seniors remain in their homes, and give family members peace of mind by monitoring their condition, in some cases using predictive analytics to determine if they are at risk.Walabot, a wall-mounted monitoring system developed by the Israeli startup Vayyar, uses radio waves and three-dimensional imaging to keep tabs on seniors living alone. The Walabot fall detection device for seniors from Israeli startup Vayyar is displayed at the 2019 Consumer Electronics Show This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Not just for kids: a leap for seniors at Vegas tech show (2019, January 11) retrieved 17 July 2019 from https://phys.org/news/2019-01-kids-seniors-vegas-tech.html Jerry Wilmink of CarePredict holds a wearable tech band that can help monitor seniors in assisted living and help predict falls or other health issues at the 2019 Consumer Electronics Showlast_img read more

Last Volkswagen Beetle drives into the sunset

first_imgPUEBLA, Mexico (Reuters) – Volkswagen (VOWG_p.DE) rolled the last Beetle off the assembly line on Wednesday, the end of the road for a car that ran from Nazi Germany through hippie counterculture but failed to navigate a swerve in consumer tastes towards SUVs. Serenaded by a mariachi band and surrounded by proud factory workers, the final units of the retro, rounded compact were celebrated at a VW plant in Mexico’s central Puebla state more than 80 years after the model was introduced in Germany. The Puebla factory, which already produces VW’s Tiguan SUV, will make the Tarek SUV in place of the Beetle starting in late 2020, Volkswagen de Mexico Chief Executive Steffen Reiche said. The bigger vehicles are more popular in the United States, the main export market for the Mexico factory. The last Beetles will be sold on Amazon.com (AMZN.O) in a move symbolizing the company’s embrace of the future, Reiche said. “Today is the last day. It has been very emotional,” he said. The current design was the third version of the Beetle after two earlier cancellations and revivals of the marque. The “bug,” as the Beetle was nicknamed, debuted in 1938 as an affordable vehicle commissioned by Adolf Hitler to promote car ownership among Germans. With its funky design and inexpensive price, the car became a success story over subsequent decades and was one of the top-selling models of all time as well as the best-selling import in the United States in the 1960s, according to auto publications. In the 1960s, the Beetle was a small-is-beautiful icon of the postwar Baby Boom generation. The 1968 movie “The Love Bug,” which featured a zany anthropomorphic vehicle, stoked Beetle fever. Despite its place in popular culture, sales of the Beetle have been lackluster in recent years. The German automaker announced in September that the Beetle would go extinct. Reporting by Sharay Angulo; writing by Stefanie Eschenbacher and Anthony Esposito; Editing by Cynthia OstermanOur Standards:The Thomson Reuters Trust Principles.last_img read more

Most Asean markets fall on weak China data Singapore edges up

first_imgEquity selling in the country was exacerbated by the central bank’s steps to curb short-term speculative capital flows in a bid to weaken the baht. A stronger local currency hurts the country’s exports. World 04 Jun 2019 Highlights: U.S. President Donald Trump’s news conference with PM May Investors now await second-quarter GDP data from China due on Monday. A Reuters poll sees growth slowing to its weakest pace in at least 27 years. SINGAPORE: Most Southeast Asian stock markets ended lower on Friday after weak trade data from China, the region’s biggest trading partner, spelt further weakness for the broader Asian economy.China’s June exports fell and imports shrank more than expected as a trade tiff with the United States continued to erode demand in the country.Fears of a resurgence in trade tensions also weighed on regional stocks after US. President Donald Trump said in a tweet that China was not living up to promises it made on buying agricultural products from American farmers. Indonesian stocks closed 0.7% lower and led regional losses, with the maximum  pressure on the benchmark coming from consumer staples and telecommunication stocks. Telekom Indonesia closed more than 2% lower, while cigarette maker Gudang Garam shed more than 3%. Related News An index of the country’s 45 most liquid stocks closed down 0.9%.     Related News Tags / Keywords: Seven of 11 economists surveyed by Reuters expect the central bank to ease policy in October after the island state saw its slowest economic expansion in a decade for the second quarter. – rEUTERS Markets World 08 Jul 2019 Ambassador leaks are a ‘matter of regret’, Britain tells U.S World 08 Jul 2019 In jab at U.S., China vice president says world cannot shut China out Singapore stocks closed slightly higher as investors bet on equities benefiting from local monetary policy easing.  Local stock indexes closed the week largely unchanged as buying in anticipation of U.S. monetary easing was offset by weaker economic readings. {{category}} {{time}} {{title}} Thai stocks ended 0.5% lower, with losses across all sectors. Oil and gas explorer PTT and hospital operator Bangkok Dusit Medical Services were among the largest drags on the benchmark.last_img read more