Compliance training and e-learning have become inseparable at Credit Suisse.We follow the financial services company’s learning audit trailCompliance training is one of today’s big challenges for training managers.But it has also given e-learning one of its greatest opportunities to shine.Nowhere is this more true than in financial services, where e-learning has madethe difference between whether global brands meet their compliance trainingobligations. Credit Suisse Group, which has its headquarters in Zurich, is one of theworld’s leading financial services companies, with 50,000 staff working in 50countries. As such a global institution, it must observe a complex set of legaland compliance regulations. The Swiss Federal Banking Commission (SFBC) has been increasing the amountof regulatory control and monitoring of the Swiss financial environment withanti-money laundering and client data protection forming two key areas offocus. In foreign locations, Credit Suisse Financial Services maintains compliancewith Swiss regulations, in addition to the policies of any regional regulatoryauthorities. Sited at every significant Credit Suisse location is a legal unitwith a legal and compliance officer, and the reporting requirements of thatofficer can differ according to the local regulatory authority. “Credit Suisse is committed to ensuring compliance with the regulatoryobligations in every location in which it operates,” says AnthonyCerquone, head of talent development and leadership technology at Credit SuisseFinancial Services. “Like all large financial institutions, this imposes an enormoustraining obligation which would be almost impossible to meet with traditionalclassroom training.” E-learning infrastructure To meet such a demand, Credit Suisse has put a robust e-learninginfrastructure in place. It comes as a result of a three-year relationship withDublin-based e-learning technology provider WBT Systems and its Swiss partnerTertia Edusoft. It began with a pilot for 20 people and following this, WBTimplemented its TopClass e-learning suite for Credit Suisse Private Banking todeliver online training to 8,500 staff. Now it is being used to deploy legal and compliance training to 50,000employees, and sales training to the group’s 4,000-strong sales team. “Over the past three years we have enjoyed a very productiverelationship with WBT,” says Cerquone. “We chose WBT because of itsunderstanding of our business. The commercial, competitive and regulatoryenvironment that we play in is very complex. WBT understands this and ishelping us respond to these challenges and to establish a robust audit-readyregulatory compliance training system.” As an aside to the e-learning implementation, WBT is also utilising itscompliance audit tool. CIARA (Compliance Infrastructure Audit ReadinessAssessment) is designed to give the CEO, board and compliance officers a viewof the organisation’s readiness to comply with relevant regulatory legislation,and successfully handle a regulatory audit. It comprises an in-depth survey ofmore than 100 questions, one-to-ones and presentations, and is based on manyyears of experience in the financial services sector. Successful pilot The initial pilot played a major part in not only testing the concept of e-learningbut also in helping to make a business case for it. As a follow-up to thepilot, which featured the use of TopClass, the 20 participants were interviewedabout what they thought of the training. The feedback was so positive, it wasused in the proposal to the board, and as a result the e-learning initiativewas brought forward by two months. The web-based TopClass suite integrates with Credit Suisse’s HR portal andallows the company to create, deploy and manage learning across theorganisation. The system has two million users worldwide and customers includeDow Chemical, US Department of Defense, Smith and Nephew and Volvo CE. Itincludes a learning management system (LMS) and a Learning Content ManagementSystem (LCMS), both of which are utilised extensively by Credit Suisse. “The LMS module allows it to create a portal for all training – online,face-to-face and blended – and users can select courses through the catalogue,through a skills gap analysis or automatic assignment based on their job ororganisational group membership,” explains Des Noctor, vice-president ofsales and services at WBT Systems. The system also caters for Credit Suisse’s band of mobile sales workforces(via TopClass Mobile), allowing staff on the road to study a course offline ontheir laptop. “They can then synchronise data back to their training record when theynext have a connection,” says Noctor. And not only can it facilitate thee-learning, but the LMS is also a valuable measuring tool for compliancetraining. “It lets you do things cheaper, faster and better, but because itrecords and tracks what you do, it also lets you demonstrate your compliancetraining to the regulatory bodies,” he says. Much of the online content behind the LMS is developed by Tertia Edusoft,and Credit Suisse itself uses the TopClass Publisher content assembly andauthoring module to create content internally. The courses also include ITtraining and soft skills as well as Credit Suisse’s own product training. TestingOne of WBT’s biggest challenges was presented by the volume and time factorsinvolved in the project, epitomised by Credit Suisse’s home-grown device fortesting itself exhaustively in-house on compliance issues. “We and our colleagues in legal and compliance have developed ‘Case ofthe Month’- a scenario-based approach to testing staff on work situations thatrequire an understanding of compliance,” says Cerquone. The course is mandatory for several thousand staff and is available toeveryone else in the organisation. It is simply presented via on-screenquestions in compliance-related areas. “The compliance department musthave absolute confidence in the reliability of TopClass as a deliveryvehicle,” says Noctor. “A different one is rolled out every month,and this demonstrates how Credit Suisse seeks to go above and beyond to audititself internally.” Credit Suisse is justified in putting such measures in place to audit itselfso rigorously – the cost of non-compliance for organisations in the financialservices sector is considerable. As well as the obvious financial consequences, the potential damage to anorganisation’s brand is also of major concern. In a White Paper written by WBT(see download details in box below, left), research conducted with complianceofficers working within financial services providers in the UK found thatdamage to the brand and reputation was the overwhelming concern of 89 per centof respondents. Second was the ability to carry on conducting businessfollowing a compliance failure, and financial penalties incurred. “Customer retention and loyalty is driven largely by the level of trustplaced by customers in a bank, insurance company or brokerage,” writesDuncan Kelly, WBT founder and chief technology officer. “Frequently this trust is implicit and only considered in the light ofthe negative publicity of a compliance failure.” ToptipsThree key criteria for e-learning Comprehensive: Provide broad functionality to grow with yourneeds from an initial departmental or tactical solution to enterprise-wideservice. Such a solution should provide capabilities in the areas of contentmanagement, learning management and performance management.Scalable: In both technical,performance terms and in terms of process support, the solution must haveproven itself to be effective in large-scale distributed enterpriseenvironments.Flexible: The system must be able togrow with your changing needs, many of which will be largely unknown today.This must include the ability to tailor the solution such as support formodifying the user interface and language support based on your organisationalneeds. Support is crucial for a variety of content types and sources, allowingyou to leverage capabilities of your subject matter experts to captureknowledge directly as well as leverage the significant investments you havemade and will continue to make in learning materials for both the classroom andthe web.From WBTSystems White Paper e-Learning and Financial Services which can be downloadedfor free at www.wbtsystems.com. (the site does request that you to registerbefore you are able to download).In summary: Credit SuisseCredit Suisse’s aim: To deliver online learning to 8,500 staff,followed by legal and compliance training to 50,000 staff and sales training to4,000 sales staff.Why? Legal and compliance trainingplaces a huge burden on training departments and without e-learning it isdoubtful that firms could fulfil the obligation. Is e-learning delivering? At the timeof writing the system was due to go live, but the pilot project was judged sucha success the e-learning initiative was advanced by two months. Individuals whoparticipated in the pilot were interviewed and the feedback received was sopositive it was used as part of the business case for e-learning when presentedto the board. Related posts:No related photos. Regulation learningOn 1 Jul 2003 in Personnel Today Comments are closed. Previous Article Next Article
FacebookTwitterLinkedInEmailAllen Kee/ESPN Images(NEW YORK) — Born into a family of athletes, Rashad Jennings had many aspirations as a kid, the biggest of which was playing running back in the NFL. Even at a young age, however, he realized his professional football dream was an uphill battle.“I grew up an overweight, chubby kid, glasses, asthma, 0.6 GPA at one point in time. Fifth string [running back] who said ‘I want to play in the NFL,’” Jennings tells ABC News, “but a lot happened from point A to point B.”Jennings grew up in Virginia and his two older brothers, Bryan and Butch, both had stints in the NFL. His mother did not want Rashad playing, knowing the physical toll it took on his brothers’ bodies. “Go on and be a lawyer or something,” she would tell him.His asthma, which he says he “literally outran,” gave doctors reservations, and he was told by medical professionals it would be better if he did not play football, but he decided to continue playing anyway.He recounts the first time he drew the attention of a college scout. His high school coaches were forced to play him due to injuries to several of his teammates. He starred, scoring touchdown after touchdown, but the college scout still rejected him, telling Jennings he needed to improve his grades to be a college athlete.The fact that the scout recognized Jennings’ athletic potential, however, marked a turning point in his youth, one that drove him to focus improving on and off the field. It set him on the path to being a professional athlete.It was his pursuit of this dream and other aspirations that inspired him to write his book The If in Life: How to Get Off Life’s Sidelines and Become Your Best Self, which was released May 8.“The ‘Gold Jacket’ was never on my mind,” he tells ABC News, referring to the jacket players receive when they are elected to the Pro Football Hall of Fame. He played eight years in the NFL, retiring in 2017, but says he was never driven to reach the hall of fame because he wants to be remembered as more than just a football player. If he is just a running back, Jennings says, he would consider that a “failure.”That mindset is the theme of his book: taking joy in the pursuit, not just the accomplishment. Proving critics wrong, outrunning asthma, and keeping his eye on his dream are the “if’s” he highlights in his book: the turning points where he had to ask himself if he really wanted to continue pursuing his NFL dream. He did just that, and continues to ask himself those questions as he takes on new goals in his life.When he joined ABC’s Dancing with the Stars, for instance, he liked the idea of learning new dance moves, but he wanted to excel and win the competition, which is exactly what he did.Now, he is a published author, and hopes to be remembered in other ways as he moves on from his NFL career.The book’s forward was written by former football player and ABC’s “Good Morning America” anchor Michael Strahan, which Jennings says is very fitting. He calls Strahan an “anomaly” because of the different things he has accomplished in his life.Jennings says Strahan’s career inspires him, and Strahan tells Jennings that he too is inspired by the former New York Giant.Although Strahan does have a gold jacket, Jennings wants to be remembered in the same way as his friend: a former football player who uses his professional career as a jumping point to do even more off the field. Copyright © 2018, ABC Radio. All rights reserved. May 12, 2018 /Sports News – National Former NFL running back Rashad Jennings discusses his path to the NFL and new book in conversation with ABC Radio Written by Beau Lund
“It’s not the most sensitive choice of theme, is it?” remarked one second-year Historian. “It can easily lead to gypsy and traveller culture being taken as something of a joke.” Professor Michael Collins, Dean of University College, told Cherwell that “no student was detained in hospital,” in response to a report that the freshers in question had been admitted. There has been much speculation as to what the college’s response to this incident will be. He also claimed that some students did not behave appropriately in response to the theme, claiming that “the fact that some people took the instruction ‘dress like a gypsy’ to mean turn up in wifebeaters with beer stains on them perhaps shows the level of insensitivity”. The bop was advertised with a passage that read, “We are the last generation, a sacred tribe, where university life is still cheap and bountiful. We must make hay while the sun of this Indian Summer shines! Yes, to dance beneath the diamond sky with one hand waving free, silhouetted by the sea, circled by the circus sands… Come with us! Cast off your materialism! Dance, make merry, eat by the fire of our youth and revel.” A controversial choice of Freshers’ Week bop theme has raised some eyebrows at Keble and around the University.“Gypsy Bop”, which the Keble Entz Officers called “a celebration of cultural diversity”, was viewed by some as overstepping the line of what is acceptable. The Keble Entz Officers maintain that the purpose of the bop was not to laugh at Gypsies, but rather to embrace the positive aspects of their culture. They told students, “Tar us not with the brush of discrimination, but strip off your clothes steeped in materialism, throw them to the floor and dance with us, naked and euphoric. Peace and love, Keble Entz.” This is not the first time Oxford bop or party themes that have been accused of being politically incorrect. Cherwell has previously reported on a “Cross-Gender bop” at St Anne’s, students ‘blacking up’ for Univ’s “Safari bop,” and the University Rugby Club’s “Bring a Fit Jew” night. In other bop-related news, rumours have been flying around Univ following its Freshers’ Week fancy dress party at which two freshers were taken to hospital for alcohol-related reasons. It appears that Gypsy Bop was widely referred to as the “Big Fat Gypsy Weddings” Bop, taking cue from the Channel 4 documentary which looked at the lives of gypsies and travellers in Britain today. However, he criticised the insensitivity of the organisers, saying, “What is shocking is that no one involved in choosing the theme even asked whether this might be considered offensive. After all, gypsies are a distinct cultural and even ethnic group. Perhaps an analogy would be to have a ‘dress-like-a-Jew bop’, something people hopefully would have realised was offensive. “As long as it’s not done in a derogatory way, I don’t see the problem with it,” said a History and Politics second year. One Keble student, speaking on condition of anonymity, told Cherwell, “My first reaction to the theme was how does one dress like a gypsy?” Cherwell’s source at Keble explained the choice of theme as being “probably all due to the fact that unlike most other ethnic groups, there are no gypsies and Keble, and indeed no one at Keble is likely to have interacted with gypsies at all, hence why nobody even really stopped to think that the theme could be offensive. The source claimed that most Keble students reacted sensibly to the theme, saying, “Most people managed to undertake the theme in vaguely good taste, for instance dressing as Esmerelda, essentially ignoring the “Big Fat” part of the theme, so your average Keblite isn’t at fault.” The Keble bop has reignited the debate over how much organizers of such events should sacrifice creative freedom for purposes of cultural sensitivity. Keble’s JCR has defended its decision to hold a gypsy-themed bop, releasing a statement saying that the “theme, decorations and publication of the party were taken with positivity and creativity.” Hubert McGreevy, former president of the Newman Society, Oxford’s oldest Roman Catholic organisation, has been previously quoted as saying, “It is right and important to be sensitive about costumes and themes which mock gender, religion and race. I may find some costumes distasteful, but I would not want to infringe students’ liberties.” “Inevitably people will hide behind the ‘it was a joke’ defence, but I wonder if people would believe them as much if they had targeted a different ethnic group, that people were more used to defending.” “I do not feel it appropriate to comment further on matters that are still under consideration; the College always take incidents such as those that occurred last weekend with the utmost seriousness,” said Professor Collins.
Two-thirds of retailers (62%) listed on the London Stock Exchange issued positive trading statements in the third quarter of 2007, with 100% of all food and drink retailers reporting an increase in like-for-like sales, according to a new report.The level of positive trading statements was the highest since chartered accountancy Grant Thornton introduced its Quoted Retail Companies Index in 2003 and was double the previous quarter’s result of 31%.The number of negative trading statements fell to 15%, down from 19% in the second quarter. Only three retailers, all in the non- food sector, issued profit warnings, said the report.David Bush, head of Grant Thornton’s retail services team, described the results as extraordinary. He believed a further interest rate rise was needed to curb consumer spending, which “is continuing unabated”.Many retailers reported that margins improved in the third quarter, highlighting, Bush said, the scope to raise selling prices in the current economic climate.
Minister Burt said: Follow Minister Burt on Twitter @AlistairBurtUK. I am shocked to hear of the attack on Palestinian Prime Minister Hamdallah’s convoy in Gaza this morning. I strongly condemn this attack, for which there is no justification. My thoughts are with those who were injured, and I wish them a speedy recovery. The UK continues to support the return of the legitimate Palestinian Authority to the Gaza Strip, and we encourage those involved to engage constructively towards this objective. We urge non-violence, dialogue and progress towards a sustainable reconciliation and an improvement in the humanitarian situation in Gaza. For journalists Follow the Foreign Office on Twitter @foreignoffice and Facebook Email [email protected] Media enquiries Further information Follow the Foreign Office on Instagram, YouTube and LinkedIn
Related Joslin, Taubes said, didn’t believe sugar itself was harmful and in fact thought it was beneficial in balancing diabetic reactions stemming from too much insulin. Stare, whose work included research funded by the sugar industry, believed that too much fat, not sugar, was the harmful factor in the diet, a view that helped shape the low-fat recommendations of the 1980s and 1990s that are widely viewed as a significant factor in the obesity epidemic.The magnitude and impact of diabetes in the U.S. can’t be overstated, Taubes said. From 1958 to 2014 there was a 750 percent increase in the prevalence of diabetes in the population, and a 1,400 percent increase in the number of cases. He cited the World Health Organization’s director general, Margaret Chan, who last year said there is “virtually zero” chance that public health specialists can prevent the “slow-motion disaster” of diabetes from getting even worse.With that grim prognosis, Taubes said it is “incomprehensible” that scientists are not intensely searching for factors that might have been overlooked. The reason for that lack of effort, he said, is that we think we already know the cause — overeating, a lack of exercise, and the food industry’s dogged efforts to make their products irresistibly appealing.Though sugar has long been a suspect in illness, its role has been obscured by both the focus on fat and an over-complication of the dietary landscape, said Taubes, citing National Institutes of Health-funded obesity studies that look at everything from a lack of sidewalks and playgrounds that deter exercise to advertising, lack of sleep, and emotional issues such as boredom, stress, and anger.Science tells us to start not with a complicated web of explanations, Taubes said, but rather with the simplest hypothesis that adequately explains the facts.Some blame lies with the Food and Drug Administration, said Taubes, pointing to a 1986 FDA study that found “no conclusive evidence” that sugar was harmful when consumed at typical levels of the time. Taubes said he actually agreed with that conclusion, but only because the sugar levels the report cited — 40 pounds per person annually — were badly out of date and reflected levels that might have existed in 1840.The actual per capita consumption at the time, according to the Department of Agriculture, was 75 pounds a year — though sugar industry production created enough for 124 pounds per person a year, and Taubes said that may have been the true consumption figure. Today, those USDA numbers are about 90 pounds per person annually, with a sugar industry production equal to 131 pounds. Too sweet for our own good Sugar was in the dock at Harvard Law School this week, accused of a prime role in the twin epidemics of obesity and diabetes sweeping the country.Science journalist and author Gary Taubes ’77 made his case that sugar consumption — which has risen dramatically over the last century — drives metabolic dysfunction that makes people sick. The hourlong talk was sponsored by the Food Law and Policy Clinic and drawn from Taubes’ new book, “The Case Against Sugar.”A reputation for “empty calories” — devoid of vitamins and nutrients but otherwise no different from other foods containing an equal number of calories — has allowed sugar to maintain a prominent place in the U.S. diet. Taubes is dubious. First, all calories are not equal because the body metabolizes different foods in different ways. More specifically, there may be something about eating too much sugar — in particular fructose, which is metabolized in the liver — that implicates it in metabolic disease.“I’m making an argument that sugar is uniquely toxic,” said Taubes. “It has deleterious effects on the human body that lead to obesity and diabetes.”Taubes laid out a case that he admitted was “largely circumstantial,” though one he considers compelling enough that it would gain at least an indictment from an impartial jury. The problem with the evidence, he said, is that public health researchers haven’t focused enough attention on sugar.“The research doesn’t exist beyond reasonable doubt that sugar is to blame,” Taubes said.Diabetes, Taubes noted, was once a rare disease. He traced its rise through the 1800s and 1900s from just a fraction of 1 percent of the cases seen at Massachusetts General Hospital to a condition that afflicts nearly 10 percent of the U.S. population, according to the Centers for Disease Control and Prevention. That increase, he said, coincides with an increase in sugar in the American diet.He tied today’s problems to both the sugar industry and some of the scientists responsible for informing the public about diet. Two researchers prominent in Harvard’s history didn’t escape blame: Elliott Joslin, the founder of the Harvard-affiliated Joslin Diabetes Center, and Frederick Stare, the founder of the Harvard T.H. Chan School of Public Health’s Nutrition Department. Panel lauds new labeling guidelines, takes aim at added sugar and salt in food, as well as some supplements
Miami All Bar Conference will review Dignity in Law program Miami All Bar Conference will review Dignity in Law program December 1, 2002 Regular News The 2003 All Bar Conference will review the Dignity in Law campaign and participants will discuss the need to increase public awareness about the role lawyers play in society.The conference will be held in conjunction with The Florida Bar’s Midyear Meeting January 16 at the Hyatt Regency in Miami. Information about the conference has been distributed to Florida Bar leaders, including the Bar Board of Governors, The Florida Bar Young Lawyers board, voluntary bar leaders, section and standing committee chairs, members of the board of The Florida Bar Foundation, and the judiciary, according to President Tod Aronovitz. Registration information also will be mailed out soon.Dignity in Law is a public awareness campaign designed to promote dignity in the profession, as well as emphasizing the need for a fair and impartial judiciary by applying an intensive, consistent communications effort. The plan also is designed to complement existing Bar public information efforts.The day long program will include media spokesperson training and a media panel discussion that will address the merits of the program and provide suggestions on how to improve the profession’s public perception. Florida journalists will appear on the panel.There also will be sessions where all attendees will critically analyze communication techniques with legislators, media, Bar members, and consumers. A professionalism seminar also will be part of the program and will be moderated by Second Circuit Judge Terry Lewis and Blan Teagle, director of the Bar’s Center for Professionalism. The participants will screen “The Good, Bad and the Ugly: Lawyers and Popular Film.” The conference will also offer lawyers continuing legal education credit.Aronovitz said the erosion of respect for the legal profession stems from its commercialization, promotion by advertisement, emphasis on profit and financial gain, as well as fast-paced competition with clients’ demands and the pursuit of legal excellence. Bar polls consistently show most Florida lawyers view journalistic attacks as unfair and ask Bar leadership “to take a stand to tell our story.”More than $250,000 has been contributed by Bar members and sections to support the Dignity in Law program, according to Toyca Williams, of the Bar’s Public Information Department. Aronovitz said he is satisfied with the program’s success so far.“We are getting the message out to all Floridians about the great work lawyers and judges do every day for their clients, in the courtrooms and in the community.”Williams said the message also has spread nationally and garnered support outside Florida. Other legal organizations have asked Aronovitz to speak to their members about Dignity in Law.“Contrary to the high profile criminal cases that the public most often associates with the legal profession, most legal work goes largely unoticed but is equally essential,” Aronovitz said. “From buying or selling a home to preparing a will, Floridians rely on attorneys to ensure that their rights and best interests are protected.”
The sooner we begin, the sooner we may say along with Sam’s old Gaffer, “All’s well that ends better!” McConnell may be right—indeed, he may continue to do damage even as we work to correct it—but we must undertake it just the same. And Tolkien provides us with insight into the way that work must be accomplished: with determination, but also with compassion. Frodo, as leader of the free hobbits, forbids violence against his fellow hobbits “even if they have gone over to the other side. Really gone over, I mean, not just obeying … because they are frightened.” He cautions that “it is useless to meet revenge with revenge: It will heal nothing.” Compare this to Joe Biden: “We must stop treating our opponents as our enemy. We are not enemies. We are Americans.” Like Trump’s MAGA minions, Saruman’s thugs—hobbit, half orc, and human alike—demand respect but deserve none. What they do deserve, Frodo knows, is the chance to change—with consequences if they choose not to. “Do not kill him even now,” he instructs Sam after the disgraced Wizard has just attempted to stab him with a dagger. “He was great once, of a noble kind … He is fallen and his cure is beyond us, but I would still spare him, in the hope that he may find it.” But Saruman’s pride, like Trump’s, prevents conversion. “All my hopes are ruined,” he tells Galadriel in an earlier chapter, “but I would not share yours.” And Frodo has no compunctions about driving him and his henchmen out of town—as we must have none about driving out the recalcitrant Trump and his goons if they refuse to go in peace. When first apprised of Sauron’s fall and the success of the Quest, Sam wonders, “Is everything sad going to come untrue?” In “The Scouring of the Shire,” Tolkien has Sam provide his own answer: “I shan’t call it the end,” he says, “till we’ve cleared up the mess. And that’ll take a lot of time and work.” That work is now our work. To quote Joe Biden, “The work of making this vision real is the task of our time.” – Advertisement – Nor have we rid ourselves of the scourge of Trumpism. On the contrary, Trumpists still occupy the top positions in government and have not acceded to the lawful transfer of power. High-level elected officials remain complicit. Trump loyalists have been installed in our judiciary and our career civil service. Armed militias threaten violence. And millions of our fellow citizens have thrown their lot in with the corrupt and immoral Trump regime. Tolkien understood that the aftermath of evil is not sudden good, but rather a long, hard, unglamorous slog towards normalcy and decency. And he understood that even this menial work would face resistance from the spiteful vanquished. “I have already done much that you will find it hard to mend or undo,” smirks Sharkey/Saruman to Frodo upon realizing he is defeated. Compare this to Mitch McConnell upon the confirmation of Amy Coney Barrett to the Supreme Court: “A lot of what we’ve done over the last four years will be undone sooner or later by the next election. They won’t be able to do much about this for a long time to come.” – Advertisement – – Advertisement –
Editor’s note: The title and first two paragraphs of this story were revised Dec 16 to correct a statement in the original that gave a more positive reflection of the trial results described below than may be warranted. The original version said that Sanofi Pasteur had described the trial results as “promising,” but the company actually said only that the results were “a sign of progress.”Dec 15, 2005 (CIDRAP News) – Sanofi Pasteur today announced preliminary trial results suggesting that using an additive to boost the immune response may help to stretch the supply of a vaccine for H5N1 avian influenza by a modest amount.Previous results had indicated that an H5N1 vaccine without an immune-boosting adjuvant would have to contain 12 times as much antigen (active ingredient) as seasonal flu vaccines do. In the results announced today, it took four times as much antigen as in a seasonal flu vaccine to induce an adequate immune response—an improvement, but far from what is needed to remedy the global shortage of vaccine production capacity.Sanofi tested an H5N1 vaccine it is making for the French government on 300 volunteers, using three different doses: 7.5, 15, and 30 micrograms. The volunteers were divided into six groups, and each group received two doses of vaccine with or without alum, an adjuvant used in many vaccines, according to Len Lavenda, US spokesman for Sanofi. The shots were given 3 weeks apart.”A 30-microgram dose with an adjuvant in a two-dose regimen demonstrated an immune response at levels consistent with requirements of regulatory agencies for licensure of seasonal influenza vaccine,” the company said in a news release.The two 30-microgram doses of vaccine containing alum induced an immune response in line with what the European Agency for Evaluation of Medicinal Products (EMEA) requires for flu vaccines, Lavenda told CIDRAP News.”We saw responses in all six groups, but the two-30-microgram-dose adjuvant group was the only one within the range of EMEA approval,” he said.”The 7.5- and 15-microgram studies provided results that were not as high as the 30, but we are continuing to study that data and we expect to publish the full set within a few months,” Lavenda said.Seasonal flu vaccines typically contain 15 micrograms of antigen, the active ingredient, for each viral strain covered. The amount that proved adequate in the Sanofi trial was 60 micrograms (two 30-microgram doses), four times as much.However, 60 micrograms is a much smaller amount than what was found to be adequate in a trial of an H5N1 vaccine that Sanofi is producing for the US government, according to results announced in August. In that trial, which didn’t involve an adjuvant, the regimen that looked most promising was two 90-microgram doses, a total of 180 micrograms.H5N1 vaccines are being developed in the hope that they will be protective if the H5N1 virus evolves into a pandemic strain. But even if the current experimental vaccines turn out be effective, the world’s current production capacity is far too small to provide enough vaccine for more than a small fraction of the population, according to disease experts. Researchers hope that dose-sparing tools such as adjuvants will help stretch the supply.Sanofi called the new trial results “a sign of progress” that will help guide further development of a pandemic flu vaccine. “Subsequent trials will explore different dosages, which may be helpful in answering questions about dose-sparing strategies,” the company said.The vaccine used in the latest trial is being developed to provide a stockpile for the French government, the company said. It comes from a different human isolate of H5N1 virus than the one used in the vaccine Sanofi is making for the United States, according to Lavenda.See also:Aug 8, 2005, CIDRAP News story “Hopeful news on human H5N1 vaccine, but production concerns considerable”
In the operations of the Franjo Tuđman Airport, 2017 will be recorded in terms of record traffic results, and for the first time in history, Zagreb Airport recorded the three millionth passenger. Lucky passenger Stephan De Bleser from Belgium checked in for Croatia Airlines flight OU4456 Zagreb – Brussels.The check-in of the three millionth passenger for the flight was accompanied by a ceremony and a musical surprise performed by the Zagreb Philharmonic Trombone Quartet, in the check-in area, thus cheering many other passengers who found themselves at the airport. “We end a successful business year in the best possible way, by marking the three millionth passenger of the airport, for the first time in history. Congratulations to Mr. De Bleser, our three millionth passenger, and I thank all the passengers who used the services of Franjo Tudjman Airport this year, in which we opened a new passenger terminal and achieved excellent traffic results.”, Said Jacques Feron.The first three millionth passenger in the history of the Franjo Tudjman Airport is the Belgian Stephan De Bleser, who stated “I was pleasantly surprised by this kind of welcome, I felt like a movie star! This is my second time in Croatia, thank you very much for the gifts, I will use the voucher immediately in the duty free shop, and since I also received airline tickets, I will return to Croatia again. “Related news: CROATIA AIRLINES FOR THE FIRST TIME IN HISTORY RECORDED TWO MILLION TRAVELERS IN ONE YEAR