Several recent studies have shown the potential value of chloroform-soluble fluorescent age pigments (FAPs) in determining the age of marine invertebrates with no permanent hard parts. The primary assumption in estimating age from FAPs is that there is a linear (or at least monotonie) increase in FAP content with time. We have tested this assumption with the trochid gastropod Monodonta lineata, a species whose age can be established unequivocally from shell growth checks. Samples of 10 age classes (1.5–10.5 yr) were obtained and FAPs extracted from lyophilised cerebral ganglia and digestive gland. The fluorescence emission spectra were similar to those reported for other organisms, though the wavelength of maximum intensity varied with tissue, sex and age. Cerebral ganglia often showed two major emission peaks, digestive gland only one. Thin-layer chromatography indicated that at least three fluorescent compounds were present in the extracts. Digestive gland total FAP content did not vary for the first 5 yr of growth, but then trebled during the next 5 yr. The tissue concentration of FAP showed no statistically significant trend. Cerebral ganglia total FAP content increased during the first 5 yr then remained constant for the next 3 yr before declining. There was a steady decline in the concentration of cerebral ganglion FAP throughout life. These patterns indicate a complex relationship between FAP content and calendar age, and indicate that (at least in Monodonta) FAPs have little practical value for determining age.
FacebookTwitterLinkedInEmailI Touch Myself Project 2018/YouTube(NEW YORK) — Serena Williams is baring herself for breast cancer awareness month.The tennis star appears topless in a new video in which she sings the song, “I Touch Myself” while covering her breasts with her hands.The 37-year-old pro shared on social media that the video took her “out of my comfort zone” but she did it to “remind women to self-check regularly.”“Early detection is key — it saves so many lives. I just hope this helps to remind women of that,” she wrote.The video is part of the I Touch Myself Project, which was launched in 2014, in partnership with bra manufacturer Berlei and inspired by Australian singer Chrissy Amphlett, who died in 2013 after battling breast cancer and multiple sclerosis.Amphlett was the frontwoman for the Australian rock band Divinyls, whose biggest hit was 1991’s “I Touch Myself.” She was 53.Copyright © 2018, ABC Radio. All rights reserved. Beau Lund Written by October 1, 2018 /Sports News – National Serena Williams bares all and sings for breast cancer awareness month
Welsh bakery chain Ferraris had its headquarters in Hirwaun, south Wales “severely damaged” after a fire broke out on 19 April.The first floor of the two-storey building at the Bryngelli industrial estate was badly burned by fire. Ten firefighters in breathing apparatus tackled the blaze with two hose reels, one main jet, a thermal imaging camera and two ventilation fans.There were no injuries and, despite the fire, all staff were said to be in work and production is continuing. Ferraris, which has 60 shops across south Wales, went into administration one week before Christmas.However, in February, the company was bought by Best Bakeries, saving 600 jobs. No-one at the company was available for comment.
A novel screening method developed by a team at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center — using CRISPR-Cas9 genome editing technology to test the function of thousands of tumor genes in mice — has revealed new drug targets that could potentially enhance the effectiveness of PD-1 checkpoint inhibitors, a promising new class of cancer immunotherapy.In findings published online today by Nature, the Dana-Farber/Boston Children’s team — led by pediatric oncologist W. Nick Haining — reports that deletion of the Ptpn2 gene in tumor cells made them more susceptible to PD-1 checkpoint inhibitors. PD-1 blockade is a drug that “releases the brakes” on immune cells, enabling them to locate and destroy cancer cells.“PD-1 checkpoint inhibitors have transformed the treatment of many cancers, and opened the door to the possibility that immunotherapy will form part of the cure for cancer,” says Haining, senior author on the new paper, who is also associate professor of pediatrics at Harvard Medical School and associate member of the Broad Institute of MIT and Harvard.Yet despite the clinical success of this new class of cancer therapy, the majority of patients don’t reap a clinical benefit from PD-1 blockade. That, Haining says, has triggered a rush of additional trials to investigate whether other drugs, when used in combination with PD-1 inhibitors, can increase the number of patients whose cancer responds to the treatment.“The challenge so far has been finding the most effective immunotherapy targets and prioritizing those that work best when combined with PD-1 inhibitors,” Haining says. “So, we set out to develop a better system for identifying new drug targets that might aid the body’s own immune system in its attack against cancer.“Our work suggests that there’s a wide array of biological pathways that could be targeted to make immunotherapy more successful,” Haining continues. “Many of these are surprising pathways that we couldn’t have predicted. For instance, without this screening approach, it wouldn’t have been obvious that Ptpn2 is a good drug target for the immunotherapy of cancer.”Sifting through thousands of potential targetsTo cast a wide net, the paper’s first author Robert Manguso, a graduate student in Haining’s lab, designed a genetic screening system to identify genes used by cancer cells to evade immune attack. He used CRISPR-Cas9, a genome editing technology that works like a pair of molecular scissors to cleave DNA at precise locations in the genetic code, to systematically knock out 2,368 genes expressed by melanoma skin cancer cells. Manguso was then able to identify which genes, when deleted, made the cancer cells more susceptible to PD-1 blockade.Manguso started by engineering the melanoma skin cancer cells so that they all contained Cas9, the “cutting” enzyme that is part of the CRISPR editing system. Then, using a virus as a delivery vehicle, he programmed each cell with a different “single guide RNA” sequence of genetic code. In combination with the Cas9 enzyme, the sgRNA codes — about 20 amino acids in length — enabled 2,368 different genes to be eliminated.By injecting the tumor cells into mice and treating them with PD-1 checkpoint inhibitors, Manguso was then able to tally up which modified tumor cells survived. Those that perished had been sensitized to PD-1 blockade as a result of their missing gene.Using this approach, Manguso and Haining first confirmed the role of two genes already known to be immune “evaders” — PD-L1 and CD47, drug inhibitors that are already in clinical trials. They then discovered a variety of new immune evaders that, if inhibited therapeutically, could enhance PD-1 cancer immunotherapy. One such newly-found gene of particular interest is Ptpn2.“Ptpn2 usually puts the brakes on the immune signaling pathways that would otherwise smother cancer cells,” Haining says. “Deleting Ptpn2 ramps up those immune signaling pathways, making tumor cells grow slower and die more easily under immune attack.”Gaining more groundWith the new screening approach in hand, Haining’s team is quickly scaling up their efforts to search for additional novel drug targets that could boost immunotherapy.Haining says the team is expanding their approach to move from screening thousands of genes at a time to eventually be able to screen the whole genome, and to move beyond melanoma to colon, lung, renal carcinoma and more. He’s assembled a large team of scientists spanning Dana-Farber/Boston Children’s and the Broad Institute to tackle the technical challenges that accompany screening efforts on such a large scale.In the meantime, while more new potential drug targets are likely around the corner, Haining’s team is taking action based on their findings about Ptpn2.“We’re thinking hard about what a Ptpn2 inhibitor would look like,” says Haining. “It’s easy to imagine making a small molecule drug that turns off Ptpn2.”In addition to Haining and Manguso, co-authors of the paper are Hans W. Pope, Margaret D. Zimmer, Flavian D. Brown, Kathleen B. Yates, Brian C. Miller, Natalie B. Collins, Kevin Bi, Martin W. LaFleur, Vikram R. Juneja, Sarah A. Weiss, Jennifer Lo, David E. Fisher, Diana Miao, Eliezer Van Allen, David E. Root, Arlene H. Sharpe, and John G. Doench.This work was supported by the Broad Institute of Harvard and MIT (BroadIgnite and BroadNext10 awards) and the National Institute of General Medical Sciences (T32GM007753).
Do your homeworkWhen taking part in a work meeting, have a roadmap for what you plan to speak on. Writing down your talking points will help you out tremendously. Factor in how much time you estimate you’ll be given for making your point and come up with concise ideas to share. Going into a meeting prepared makes all the difference and will help boost your confidence.Stay informedAlways be up to speed on current events and issues others at work are interested in. That way when your coworkers talk socially around the office you will have things to input. There’s nothing worse than being clueless about what’s being discussed so although you don’t need to be an expert, knowing the basics will help you to be less reserved.Always be approachableIf others see you as pleasant and friendly then they’ll likely enjoy your presence and your company. When your coworkers like being around you, you will inevitably feel less shy and nervous. There are various personality traits the most likable people possess and a positive and open demeanor is certainly one of them.Take notesWatch very closely how the most personable and outgoing employees in your office interact with others. Model yourself after them and give yourself room to grow. Going from being shy to being more extroverted will not happen overnight so don’t be too hard on yourself. The more you let you your guard down and open up, the more comfortable you will feel with those around you. 15SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Wendy Moody Wendy Moody is a Senior Editor with CUInsight.com. Wendy works with the editorial team to help edit the content including current news, press releases, jobs and events. She keeps … Web: www.cuinsight.com Details
– Advertisement – – Advertisement – – Advertisement – Before winning the World Championship, Peter Wright explained the story behind his walk-on and that trademark dance move on the stage In the third of our series, the world champion Peter Wright tells us the story behind his walk-on song and dance.Back on January 1 as Peter Wright lifted the Sid Waddell trophy, no one could have imagined how this year was going to pan out.Listen to the Darts Show podcast on: Spotify | Apple | CastboxFollowing that famous evening, Wright would have been relishing visiting arenas all over the world, being introduced as the world champion and entertaining sell-out crowds with his colourful outfits and legendary walk-on dance.However, since the global pandemic, walk-ons have become a little different which gives us even more reason to remind ourselves of how Wright, winner of the European Championship at the weekend, usually makes his entrance. 3:24 Before winning the World Championship, Peter Wright explained the story behind his walk-on and that trademark dance move on the stage In the latest special series from The Darts Show podcast Wright tells us the story behind his walk-on song, the dance that gets every party started and the Snakebite persona that he adorns for the stage; Download & subscribe to The Darts Show podcast via Spotify By Henry ChardLast Updated: 03/11/20 6:29am
To access this article REGISTER NOWWould you like print copies, app and digital replica access too? SUBSCRIBE for as little as £5 per week. Would you like to read more?Register for free to finish this article.Sign up now for the following benefits:Four FREE articles of your choice per monthBreaking news, comment and analysis from industry experts as it happensChoose from our portfolio of email newsletters
Earlier on Wednesday, China opened its new national security office, turning a hotel near a city-center park that has been one of the most popular venues for pro-democracy protests into its new headquarters.Both Hong Kong and Chinese government officials have said the new law is vital to plug gaping holes in national security defenses exposed by the anti-government and anti-China protests that rocked the city in the past year.They have argued the city failed to pass such laws by itself as required under its mini-constitution, known as the Basic Law.Critics of the law see it as a tool to crush dissent, while supporters say it will bring stability to the city.In a statement last month, China’s Hong Kong Liaison Office, Beijing’s top representative office in the city, blamed political groups “with ulterior motives” for “shocking chaos in Hong Kong education. Authorities also banned protest slogans as the new laws came into force last week.The sweeping legislation that Beijing imposed on the former British colony punishes what China defines as secession, subversion, terrorism and collusion with foreign forces, with up to life in prison.Secretary for Education Kevin Yeung, responding to a question from a lawmaker, said students should not participate in class boycotts, chant slogans, form human chains or sing songs that contain political messages.”The song ‘Glory to Hong Kong’, originated from the social incidents since June last year, contains strong political messages and is closely related to the social and political incidents, violence and illegal incidents that have lasted for months,” Yeung said. “Schools must not allow students to play, sing or broadcast it in schools.” Hong Kong authorities on Wednesday banned school students from singing of “Glory to Hong Kong”, the unofficial anthem of the pro-democracy protest movement, just hours after Beijing set up its new national security bureau in the Chinese-ruled city.New security legislation imposed on Hong Kong by Beijing requires the Asian financial hub to “promote national security education in schools and universities and through social organizations, the media, the internet”.The school anthem ban will further stoked concerns that new security laws will crush freedoms in China’s freest city, days after public libraries removed books by some prominent pro-democracy figures from their shelves. Topics :
More than 60% of the world’s largest public pension funds have “little or no strategy” on climate change, according to new research. According to the Asset Owners Disclosure Project (AODP), part of responsible investment campaign group ShareAction, 63 of the world’s 100 largest public pension funds provide very little to no information on the financial implications of climate change for their portfolios.It said this put them at risk of breaching their fiduciary duties.Only a handful of public pension funds, mostly based in Europe, were showing “true leadership on climate change, demonstrating robust approaches to aligning their investments with the low-carbon transition”, AODP said in its assessment of the funds’ response to climate-related risks and opportunities. The analysis, which it said was the first to be published about pension funds using the framework developed by the Financial Stability Board’s Task Force on Climate-related Financial Disclosures (TCFD), formed the basis for a rating and ranking of the funds.Sweden’s AP4 and France’s Fonds de Reserve pour les Retraites (FRR) were the only funds to receive the top AAA rating.The lowest-ranked European funds, graded ‘D’, were the Railways Pension Scheme and the Electricity Supply Pension Scheme in the UK, Sampension in Denmark and BVK in Germany.The other UK pension fund captured by the research – Universities Superannuation Scheme, the country’s largest – was rated CCC, with ShareAction’s AODP noting that the UK funds were lagging some of compatriot insurance companies and smaller pension funds.Several well-known Dutch and Nordic pension funds were assigned ratings in the BBB to B and CCC to C rating brackets.Mickaël Hellier, head of responsible investment at FRR, said: “Being recognised as a leader with an AAA rating in the AODP 2018 pensions index reflects the work FRR is doing to address climate change as a long-term material financial risk.“We value this report by AODP, which highlights that the industry has a long way to go in accounting for climate change in investments and working to accelerate the transition to a low-carbon economy.”The AODP also calculated that the world’s 100 biggest public pension funds were investing $90bn (€78bn) in low-carbon technology, representing less than 1% of their combined assets of more than $11trn.Only 10% of the assessed pension funds had introduced policies to exclude coal from their investment portfolio, added the AODP.European and UK pension fund rating distributionAAA to A bracket: AP4, FRR, ABP, Varma, Government Pension Fund Global, AP3, IlmarinenBBB to B bracket: PFZW, BpfBouw, AP7, AP2, ATP, PFA Pension, Keva, AP1, PME, PMTCCC to C bracket: USS, PensionDanmark, AMF Pension, Alecta, PublicaD: Railways Pension Scheme, Sampension*, Bayerische Versorgungskammer (BVK), Electricity Supply Pension SchemeThe full report can be found here. * Sampension recently announced that it was adopting the TCFD reporting guidelines.
Norwegian shipowner and operator 2020 Bulkers has accepted delivery of Bulk Sydney, the sixth of eight 208,000 dwt Newcastlemax newbuilds.The 224,100 cbm Capesize bulker was handed over to the company by China’s New Times Shipbuilding.The Liberia-flagged vessel will on January 23, 2020, commence a three-year index-linked time charter with Koch Shipping.As explained, the index-linked rate reflects a significant premium to a standard Capesize as a function of higher cargo intake and lower fuel consumption. The vessel will also earn an additional premium related to the fuel cost saving from the scrubber.2020 Bulkers has six vessels in operation and two Newcastlemax dry bulk vessels under construction at the abovementioned Chinese shipyard. All vessels will be fitted with exhaust scrubber systems. The remaining units are expected to be delivered by May 2020.RelatedFifth Newbuild Joins 2020 Bulkers2020 Bulkers, Koch Extend Charters for Two Ships